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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Karpen, SJ; Trauner, M.
The new therapeutic frontier--nuclear receptors and the liver.
J Hepatol. 2010; 52(3):455-462 Doi: 10.1016/j.jhep.2009.12.002
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Führende Autor*innen der Med Uni Graz
Trauner Michael
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Abstract:
A joint EASL/AASLD Monothematic Conference on 'Nuclear Receptors and Liver Disease' was held from February 27th to March 1st, 2009, in Vienna, Austria, to discuss the latest advances at the forefront of basic and clinical nuclear receptor research and its potential implications for liver diseases. This article reports the highlights of the conference and summarizes the main conclusions emphasizing the relevance for clinical and experimental hepatology. The confluence of nuclear receptors as central transcriptional regulators, acting as sensors and adaptors to many of the small molecules present in the intracellular milieu of all the cells of the liver, provides a current framework to address a broader physiological understanding of the liver. The next stage will be the design and testing of safe and effective therapeutics.
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Humans -
Inflammation - physiopathology
Lipid Metabolism - physiology
Liver - physiology
Liver Diseases - physiopathology Liver Diseases - therapy
Liver Regeneration - physiology
Metabolic Detoxication, Drug - physiology
Polymorphism, Genetic - physiology
Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology
Transcription Factors - physiology

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Nuclear receptor
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