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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Neschen, S; Morino, K; Dong, J; Wang-Fischer, Y; Cline, GW; Romanelli, AJ; Rossbacher, JC; Moore, IK; Regittnig, W; Munoz, DS; Kim, JH; Shulman, GI.
n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.
Diabetes. 2007; 56(4): 1034-1041.
Doi: 10.2337/db06-1206
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- Co-Autor*innen der Med Uni Graz
- Regittnig Werner
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- Abstract:
- Recent studies have suggested that n-3 fatty acids, abundant in fish oil, protect against high-fat diet-induced insulin resistance through peroxisome proliferator-activated receptor (PPAR)-alpha activation and a subsequent decrease in intracellular lipid abundance. To directly test this hypothesis, we fed PPAR-alpha null and wild-type mice for 2 weeks with isocaloric high-fat diets containing 27% fat from either safflower oil or safflower oil with an 8% fish oil replacement (fish oil diet). In both genotypes the safflower oil diet blunted insulin-mediated suppression of hepatic glucose production (P < 0.02 vs. genotype control) and PEPCK gene expression. Feeding wild-type mice a fish oil diet restored hepatic insulin sensitivity (hepatic glucose production [HGP], P < 0.002 vs. wild-type mice fed safflower oil), whereas in contrast, in PPAR-alpha null mice failed to counteract hepatic insulin resistance (HGP, P = NS vs. PPAR-alpha null safflower oil-fed mice). In PPAR-alpha null mice fed the fish oil diet, safflower oil plus fish oil, hepatic insulin resistance was dissociated from increases in hepatic triacylglycerol and acyl-CoA but accompanied by a more than threefold increase in hepatic diacylglycerol concentration (P < 0.0001 vs. genotype control). These data support the hypothesis that n-3 fatty acids protect from high-fat diet-induced hepatic insulin resistance in a PPAR-alpha-and diacylglycerol-dependent manner.
- Find related publications in this database (using NLM MeSH Indexing)
- Acyl Coenzyme A - metabolism
- Animals -
- Diglycerides - metabolism
- Fatty Acids, Omega-3 - pharmacology
- Gene Expression Regulation - drug effects
- Glucose Clamp Technique -
- Insulin - pharmacology
- Insulin Resistance -
- Male -
- Mice -
- Mice, Knockout -
- PPAR alpha - deficiency PPAR alpha - drug effects PPAR alpha - genetics
- Reverse Transcriptase Polymerase Chain Reaction -
- Triglycerides - metabolism