Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Ritsch, A; Scharnagl, H; Eller, P; Tancevski, I; Duwensee, K; Demetz, E; Sandhofer, A; Boehm, BO; Winkelmann, BR; Patsch, JR; März, W.
Cholesteryl ester transfer protein and mortality in patients undergoing coronary angiography: the Ludwigshafen Risk and Cardiovascular Health study.
Circulation. 2010; 121(3): 366-374. Doi: 10.1161/CIRCULATIONAHA.109.875013 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz: Eller Philipp; März Winfried; Scharnagl Hubert
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Abstract:: Background-The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still open to debate. In the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial, inhibition of CETP in patients with high cardiovascular risk was associated with increased high-density lipoprotein levels but increased risk of cardiovascular morbidity and mortality. In this report, we present a prospective observational study of patients referred to coronary angiography in which CETP was examined in relation to morbidity and mortality. Methods and Results-CETP concentration was determined in 3256 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study who were referred to coronary angiography at baseline between 1997 and 2000. Median follow-up time was 7.75 years. Primary and secondary end points were cardiovascular and all-cause mortality, respectively. CETP levels were higher in women and lower in smokers, in diabetic patients, and in patients with unstable coronary artery disease, respectively. In addition, CETP levels were correlated negatively with high-sensitivity C-reactive protein and interleukin-6. After adjustment for age, sex, medication, coronary artery disease status, cardiovascular risk factors, and diabetes mellitus, the hazard ratio for death in the lowest CETP quartile was 1.33 (1.07 to 1.65; P = 0.011) compared with patients in the highest CETP quartile. Corresponding hazard ratios for death in the second and third CETP quartiles were 1.17 (0.92 to 1.48; P = 0.19) and 1.10 (0.86 to 1.39; P = 0.46), respectively. Conclusions-We interpret our data to suggest that low endogenous CETP plasma levels per se are associated with increased cardiovascular and all-cause mortality, challenging the rationale of pharmacological CETP inhibition. (Circulation. 2010;121:366-374.)
Find related publications in this database (using NLM MeSH Indexing): Aged -; Biological Markers - blood; C-Reactive Protein - metabolism; Cholesterol Ester Transfer Proteins - blood; Coronary Angiography - statistics and numerical data; Coronary Artery Disease - mortality Coronary Artery Disease - physiopathology Coronary Artery Disease - radiography; Female -; Follow-Up Studies -; Humans -; Interleukin-6 - blood; Lipoproteins - blood; Male -; Middle Aged -; Morbidity -; Proportional Hazards Models -; Referral and Consultation - statistics and numerical data; Risk Factors -
Find related publications in this database (Keywords): atherosclerosis; coronary disease; lipoproteins; mortality; risk factors