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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Peskar, BM; Ehrlich, K; Schuligoi, R; Peskar, BA.
Role of lipoxygenases and lipoxin A(4)/annexin-1 receptor in gastric protection induced by 20% ethanol or sodium salicylate in rats.
Pharmacology. 2009; 84(5): 310-313.
Doi: 10.1159/000248165
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
- Schuligoi Rufina
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- Abstract:
- The role of cyclooxygenases and prostaglandins in experimental models of gastroprotection is well established. We investigated the effects of the 5-lipoxygenase inhibitor A63162, the 12-lipoxygenase inhibitor baicalein and the 15-lipoxygenase inhibitor PD146176 as well as the nonspecific lipoxin A(4)/annexin-1 antagonist Boc1 on adaptive protection induced by 20% ethanol against 70% ethanol, and on protection induced by sodium salicylate against the mucosal-damage-aggravating effects of celecoxib and dexamethasone during local ischemia-reperfusion in rats. It was found that both types of gastroprotection were antagonized by the lipoxygenase inhibitors and the lipoxin A(4)/annexin-1 antagonist in doses that have no direct damaging effect on gastric mucosa. The results suggest that not only cyclooxygenases, but also active lipoxygenases and, possibly, annexin-1 are required for these types of gastroprotection to occur.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetamides - pharmacology
- Animals -
- Annexins - metabolism
- Cyclooxygenase 2 Inhibitors - pharmacology
- Cyclooxygenase Inhibitors - pharmacology
- Dexamethasone - pharmacology
- Drug Interactions -
- Ethanol - pharmacology
- Flavanones - pharmacology
- Fluorenes - pharmacology
- Gastric Mucosa - blood supply
- Glucocorticoids - pharmacology
- Lipoxygenase - physiology
- Lipoxygenase Inhibitors - pharmacology
- Male -
- Oligopeptides - pharmacology
- Phenyl Ethers -
- Prostaglandin Antagonists - pharmacology
- Pyrazoles - pharmacology
- Rats -
- Rats, Wistar -
- Receptors, Formyl Peptide - physiology
- Receptors, Lipoxin - antagonists and inhibitors
- Reperfusion Injury - metabolism
- Sodium Salicylate - pharmacology
- Sulfonamides - pharmacology
- Find related publications in this database (Keywords)
- Gastric mucosal damage
- Ischemia-reperfusion
- Ethanol damage
- Adaptive protection
- Sodium salicylate
- Lipoxygenase
- Lipoxin A(4)/annexin-1 receptor
- Cyclooxygenase