Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Peskar, BM; Ehrlich, K; Schuligoi, R; Peskar, BA.
Role of lipoxygenases and the lipoxin A(4)/annexin 1 receptor in ischemia-reperfusion-induced gastric mucosal damage in rats.
Pharmacology. 2009; 84(5): 294-299.
Doi: 10.1159/000244017
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Peskar Bernhard
- Schuligoi Rufina
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Rat gastric mucosal damage was induced by ischemia-reperfusion. The 5-lipoxygenase inhibitors MK886 and A63162, the 12-lipoxygenase inhibitor baicalein, the 15-lipoxygenase inhibitor PD146176 and the lipoxin (LX) A(4)/annexin 1 antagonist Boc1 increased mucosal damage in a dose-dependent manner. Low doses of these compounds, which have no effects on mucosal integrity, cause severe damage when combined with low doses of indomethacin, celecoxib or dexamethasone. 16,16-Dimethylprostaglandin (PG) E(2) and LXA(4) can replace each other in preventing mucosal injury induced by either cyclooxygenase or lipoxygenase inhibitors. The results suggest that not only cyclooxygenases, but also lipoxygenases have a role in limiting gastric mucosal damage during ischemia-reperfusion.
- Find related publications in this database (using NLM MeSH Indexing)
- 16,16-Dimethylprostaglandin E2 - pharmacology
- Acetamides - pharmacology
- Animals -
- Annexins - metabolism
- Anti-Ulcer Agents - pharmacology
- Cyclooxygenase Inhibitors - pharmacology
- Dexamethasone - pharmacology
- Drug Synergism -
- Flavanones - pharmacology
- Fluorenes - pharmacology
- Gastric Mucosa - blood supply
- Glucocorticoids - pharmacology
- Indoles - pharmacology
- Indomethacin - pharmacology
- Lipoxygenase - physiology
- Lipoxygenase Inhibitors - pharmacology
- Male -
- Oligopeptides - pharmacology
- Phenyl Ethers -
- Prostaglandin Antagonists - pharmacology
- Pyrazoles - pharmacology
- Rats -
- Rats, Wistar -
- Receptors, Formyl Peptide - physiology
- Receptors, Lipoxin - antagonists and inhibitors
- Reperfusion Injury - drug therapy
- Sulfonamides - pharmacology
- Find related publications in this database (Keywords)
- Gastric mucosal damage
- Ischemia-reperfusion
- Lipoxygenases
- Lipoxin A(4)/annexin 1 receptor
- Cyclooxygenases