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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wagner, M; Zollner, G; Trauner, M.
New molecular insights into the mechanisms of cholestasis.
J Hepatol. 2009; 51(3): 565-580.
Doi: 10.1016/j.jhep.2009.05.012
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- Führende Autor*innen der Med Uni Graz
- Trauner Michael
- Wagner Martin
- Co-Autor*innen der Med Uni Graz
- Zollner Gernot
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- Abstract:
- Recent progress in basic research has enhanced our understanding of the molecular mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter variants contribute to an entire spectrum of cholestatic liver diseases and can cause hereditary cholestatic syndromes or determine susceptibility and disease progression in acquired cholestatic disorders. Cholestasis is associated with complex transcriptional and post-transcriptional alterations of hepatobiliary transporters and enzymes participating in bile formation. Ligand-activated nuclear receptors for bile acids and other biliary compounds play a key role in the regulation of genes required for bile formation. Pharmacological interventions in cholestasis may aim at modulating such novel regulatory pathways. This review will summarize the principles of molecular alterations in cholestasis and will give an overview of potential clinical implications.
- Find related publications in this database (using NLM MeSH Indexing)
- ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - physiology
- Bile - metabolism
- Cholestasis - chemically induced Cholestasis - genetics Cholestasis - physiopathology
- Humans -
- Membrane Transport Proteins - genetics Membrane Transport Proteins - physiology
- Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology
- Signal Transduction - physiology
- Find related publications in this database (Keywords)
- Cholestasis
- Bile acids
- Hepatobiliary transporters
- Nuclear receptors