Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jahnel, J; Fickert, P; Langner, C; Högenauer, C; Silbert, D; Gumhold, J; Fuchsbichler, A; Trauner, M.
Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice.
Liver Int. 2009; 29(9):1316-1325
Doi: 10.1111/j.1478-3231.2009.02044.x
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Jahnel Jörg
- Trauner Michael
- Co-Autor*innen der Med Uni Graz
- Fickert Peter
- Hoegenauer Christoph
- Langner Cord
- Silbert-Wagner Dagmar
- Sommer Judith
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The pathogenetic link between ulcerative colitis and sclerosing cholangitis (SC) is unclear. We hypothesized that colitis induces changes in bile composition via inflammation-induced reduction of hepatobiliary transporter gene expression, ultimately resulting in cholestasis and bile duct injury. Alterations in transporter expression and bile secretion in acute dextran sulphate sodium (DSS)-induced colitis were compared with lipopolysaccharide (LPS)-treated mice serving as positive control. Whether chronic DSS-colitis elicits cholangitis in genetically predisposed animals was studied in heterozygous multidrug resistance gene 2 knockout mice (Mdr2(+/-)). LPS but not DSS-colitis changed major hepatobiliary transporters (Ntcp, Bsep, Mrp2-4, Ostalpha/beta, Abcg5/8, Oatp1-4, Mdr1b and Mdr2), enzymes (Cyp3a11 and Cyp7a1), nuclear receptors (RXRalpha, FXR, CAR and PXR) and proinflammatory mediators (tumour necrosis factor alpha and inducible nitric oxide synthase). Formation of toxic bile reflected by an increased bile acid/phospholipid ratio was observed neither in acute nor in chronic colitis, although heterozygous Mdr2(+/-) mice developed mild portal inflammation after chronic colitis. In contrast to LPS, DSS-colitis has a minor impact on hepatobiliary gene expression and bile secretion. Therefore, intestinal inflammation-associated changes of hepatobiliary transporter expression do not play a pathogenetic role in SC.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bacterial Translocation -
- Bile - chemistry Bile - secretion
- Bile Acids and Salts - analysis
- Bile Ducts - metabolism
- Carrier Proteins - genetics
- Cholangitis, Sclerosing - etiology
- Colitis - chemically induced Colitis - complications Colitis - metabolism
- Dextran Sulfate - toxicity
- Lipopolysaccharides - toxicity
- Liver - drug effects Liver - metabolism Liver - pathology
- Male -
- Mice -
- Mice, Inbred C57BL -
- Phospholipids - analysis
- RNA, Messenger - analysis
- Find related publications in this database (Keywords)
- bile acid transport and metabolism
- colitis
- Mdr2 knockout mice
- primary sclerosing cholangitis