Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Chantepie, S; Malle, E; Sattler, W; Chapman, MJ; Kontush, A.
Distinct HDL subclasses present similar intrinsic susceptibility to oxidation by HOCl.
Arch Biochem Biophys. 2009; 487(1): 28-35.
Doi: 10.1016/j.abb.2009.05.005
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Malle Ernst
- Sattler Wolfgang
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The heme protein myeloperoxidase (MPO) functions as a catalyst for lipoprotein oxidation. Hypochlorous acid (HOCl), a potent two-electron oxidant formed by the MPO-H(2)O(2)-chloride system of activated phagocytes, modifies antiatherogenic high-density lipoprotein (HDL). The structural heterogeneity and oxidative susceptibility of HDL particle subfractions were probed with HOCl. All distinct five HDL subfraction were modified by HOCl as demonstrated by the consumption of tryptophan residues and free amino groups, cross-linking of apolipoprotein AI, formation of HOCl-modified epitopes, increased electrophoretic mobility and altered content of unsaturated fatty acids in HDL subclasses. Small, dense HDL3 were less susceptible to oxidative modification than large, light HDL2 on a total mass basis at a fixed HOCl:HDL mass ratio of 1:32, but in contrast not on a particle number basis at a fixed HOCl:HDL molar ratio of 97:1. We conclude that structural and physicochemical differences between HDL subclasses do not influence their intrinsic susceptibility to oxidative attack by HOCl.
- Find related publications in this database (using NLM MeSH Indexing)
- Atherosclerosis - blood Atherosclerosis - etiology
- Blood Protein Electrophoresis -
- Electrophoresis, Agar Gel -
- Fatty Acids, Unsaturated - analysis
- Humans -
- Hypochlorous Acid - pharmacology
- Lipoproteins, HDL - blood Lipoproteins, HDL - chemistry Lipoproteins, HDL - classification Lipoproteins, HDL - drug effects
- Lipoproteins, HDL2 - blood Lipoproteins, HDL2 - chemistry Lipoproteins, HDL2 - drug effects
- Lipoproteins, HDL3 - blood Lipoproteins, HDL3 - chemistry Lipoproteins, HDL3 - drug effects
- Oxidants - pharmacology
- Oxidation-Reduction -
- Tryptophan - chemistry
- Find related publications in this database (Keywords)
- Antiatherogenic lipoprotein
- Hypochlorite
- Myeloperoxidase-hydrogen peroxide-halide system
- Tryptophan residues
- Lysine modification
- Apolipoprotein Al