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SHR Neuro Cancer Cardio Lipid Metab Microb
Sacks, FM; Rudel, LL; Conner, A; Akeefe, H; Kostner, G; Baki, T; Rothblat, G; de la Llera-Moya, M; Asztalos, B; Perlman, T; Zheng, CY; Alaupovic, P; Maltais, JAB; Brewer, HB.
Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo.
J LIPID RES. 2009; 50(5): 894-907.
Doi: 10.1194/jlr.M800622-JLR200
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- Co-authors Med Uni Graz
- Kostner Gerhard
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- Abstract:
- Uptake of cholesterol from peripheral cells by nascent small HDL circulating in plasma is necessary to prevent atherosclerosis. This process, termed reverse cholesterol transport, produces larger cholesterol-rich HDL that transfers its cholesterol to the liver facilitating excretion. Most HDL in plasma is cholesterol-rich. We demonstrate that treating plasma with a novel selective delipidation procedure converts large to small HDL [HDL-selectively delipidated (HDL-sdl)]. HDL-sdl contains several cholesterol-depleted species resembling small alpha, prebeta-1, and other prebeta forms. Selective delipidation markedly increases efficacy of plasma to stimulate ABCA1-mediated cholesterol transfer from monocytic cells to HDL. Plasma from African Green monkeys underwent selective HDL delipidation. The delipidated plasma was reinfused into five monkeys. Prebeta-1-like HDL had a plasma residence time of 8 +/- 6 h and was converted entirely to large alpha-HDL having residence times of 13-14 h. Small alpha-HDL was converted entirely to large alpha-HDL. These findings suggest that selective HDL delipidation activates reverse cholesterol transport, in vivo and in vitro. Treatment with delipidated plasma tended to reduce diet-induced aortic atherosclerosis in monkeys measured by intravascular ultrasound. These findings link the conversion of small to large HDL, in vivo, to improvement in atherosclerosis.
- Find related publications in this database (using NLM MeSH Indexing)
- ATP-Binding Cassette Transporters - metabolism
- Animals -
- Aorta - pathology
- Apolipoprotein A-I - metabolism
- Atherosclerosis - pathology
- Biological Transport -
- Cell Line -
- Cercopithecus aethiops -
- Cholesterol - metabolism
- Humans -
- Lipid Metabolism -
- Lipoproteins, HDL - metabolism
- Lipoproteins, LDL - blood
- Mice -
- Scavenger Receptors, Class B - metabolism
- Find related publications in this database (Keywords)
- apolipoprotein A-I
- kinetics
- lipoproteins
- nonhuman primates
- ABCA1
- SRB1
- pre beta-1