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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Riederer, M; Erwa, W; Zimmermann, R; Frank, S; Zechner, R.
Adipose tissue as a source of nicotinamide N-methyltransferase and homocysteine.
Atherosclerosis. 2009; 204(2):412-417
Doi: 10.1016/j.atherosclerosis.2008.09.015
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Riederer Monika
- Co-Autor*innen der Med Uni Graz
- Erwa Wolfgang
- Frank Sasa
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- Abstract:
- Nicotinamide N-methyltransferase (NNMT) catalyses the conversion of nicotinamide to 1-methylnicotinamide and plays an important role in hepatic detoxification reactions. Here we show that, in addition to the liver, 3T3-L1 adipocytes as well as human and murine adipose tissue explants express high amounts of enzymatically active NNMT. NNMT mRNA levels and enzyme activity increased in 3T3-L1 cells in a differentiation-dependent manner. Homocysteine, the atherogenic product of the NNMT-catalyzed reaction, was secreted from 3T3-L1 cells or adipose tissue cultures. Homocysteine release increased during 3T3-L1 differentiation and was reduced when adipose tissue was treated with the NNMT inhibitor 1-methylnicotinamide. Nicotinic acid (NA), a widely used drug to lower elevated plasma lipid levels, induced NNMT enzyme activity in white adipose tissue of mice. In tissue culture nicotinamide treatment led to an increase in adipose tissue homocysteine secretion. These data support the concept that adipose tissue NNMT contributes to the increased plasma homocysteine levels in patients treated with NA.
- Find related publications in this database (using NLM MeSH Indexing)
- 3T3-L1 Cells -
- Adipocytes - drug effects Adipocytes - enzymology
- Adipogenesis -
- Adipose Tissue - drug effects Adipose Tissue - enzymology
- Animals -
- Enzyme Inhibitors - pharmacology
- Female -
- Gene Expression Regulation, Enzymologic -
- Homocysteine - metabolism
- Humans -
- Hypolipidemic Agents - pharmacology
- Male -
- Mice -
- Mice, Inbred C57BL -
- Niacin - pharmacology
- Niacinamide - analogs & derivatives Niacinamide - pharmacology
- Nicotinamide N-Methyltransferase - antagonists & inhibitors Nicotinamide N-Methyltransferase - genetics Nicotinamide N-Methyltransferase - metabolism
- RNA, Messenger - metabolism
- Time Factors -
- Find related publications in this database (Keywords)
- NNMT
- Nicotinamide
- Methyltransferase
- Adipose tissue
- Homocysteine
- Nicotinic acid
- Atherosclerosis