Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

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Silbernagel, G; Fauler, G; Renner, W; Landl, EM; Hoffmann, MM; Winkelmann, BR; Boehm, BO; März, W.
The relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease.
J Lipid Res. 2009; 50(2):334-341 Doi: 10.1194/jlr.P800013-JLR200 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz: März Winfried; Silbernagel Günther
Co-Autor*innen der Med Uni Graz: Fauler Günter; Matzhold Eva-Maria; Renner Wilfried
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Abstract:: Changes in the balance of cholesterol absorption and synthesis and moderately elevated plasma plant sterols have been suggested to be atherogenic. Measuring cholestanol, lathosterol, campesterol, and sitosterol, we investigated the relationships of cholesterol metabolism and plasma plant sterols with the severity of coronary artery disease (CAD) in 2,440 participants of the Ludwigshafen Risk and Cardiovascular health (LURIC) study. The coronary status was determined by angiography, and the severity of CAD was assessed by the Friesinger Score (FS). An increase in the ratio of cholestanol to cholesterol was associated with high FS (P = 0.006). In contrast, a high ratio of lathosterol to cholesterol went in parallel with low FS (P < 0.001). Whereas the campesterol to cholesterol ratio significantly correlated with the FS (P = 0.026), the relationship of the sitosterol to cholesterol ratio with the FS did not reach statistical significance in the whole group. Increased campesterol, sitosterol, and cholestanol to lathosterol ratios were associated high FS (P < 0.001). To conclude, there is a modest association of high cholesterol absorption and low cholesterol synthesis with an increased severity of CAD. An atherogenic role of plasma plant sterols themselves, however, seems unlikely in subjects without sitosterolaemia.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Cholestanol - blood Cholestanol - metabolism; Cholesterol - analogs & derivatives Cholesterol - blood Cholesterol - metabolism; Cholesterol, HDL - blood Cholesterol, HDL - metabolism; Cholesterol, LDL - blood Cholesterol, LDL - metabolism; Coronary Artery Disease - blood Coronary Artery Disease - metabolism Coronary Artery Disease - radiography; Female -; Humans -; Male -; Middle Aged -; Phytosterols - blood Phytosterols - metabolism; Sitosterols - blood Sitosterols - metabolism
Find related publications in this database (Keywords): cholesterol absorption; cholesterol synthesis; phytosterols; campesterol; sitosterol; cholestanol; lathosterol