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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Van Eck, M; Hoekstra, M; Hildebrand, RB; Yaong, Y; Stengel, D; Kruijt, JK; Sattler, W; Tietge, UJF; Ninio, E; Van Berkel, TJC; Pratico, D.
Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL.
Arterioscler Thromb Vasc Biol. 2007; 27(11):2413-2419
Doi: 10.1161/ATVBAHA.107.145474
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- Co-Autor*innen der Med Uni Graz
- Sattler Wolfgang
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- Abstract:
- OBJECTIVE: In the current study the effect of disruption of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well as in vivo oxidative stress were investigated. METHODS AND RESULTS: SR-BI deficiency resulted in 1.4-fold (P<0.001) and 1.6-fold (P<0.01) lower serum paraoxonase and arylesterase activity of PON1, respectively. Furthermore, a trend to slightly lower PAF-AH activity was observed. In vivo oxidative stress was evaluated by measuring isoprostane F2alpha-VI (iPF2alpha-VI) and protein carbonyls. Compared with wild-type animals, SR-BI knockouts had 1.4-fold (P<0.05) higher levels of plasma iPF2alpha-VI, whereas urinary excretion was increased 2-fold (P<0.0001). Plasma carbonyls were 1.5-fold (P<0.05) higher in SR-BI knockout animals. Furthermore, iPF2alpha-VI and carbonyl levels were 2.1-fold (P<0.01) and 1.4-fold (P<0.01), respectively, increased in livers of SR-BI knockout mice, and in reaction to the increased oxidative stress the expression of several endogenous antioxidant systems was upregulated. On challenging the SR-BI knockout mice with an atherogenic Western-type diet, a further increase in oxidative stress in these animals was observed. CONCLUSION: SR-BI deficiency results in a reduced activity of the antioxidant enzyme PON1 and a significant increase in oxidative stress, potentially contributing to the proatherogenic effect of SR-BI deficiency.
- Find related publications in this database (using NLM MeSH Indexing)
- 1-Alkyl-2-acetylglycerophosphocholine Esterase - blood
- Animals - blood
- Aryldialkylphosphatase - blood
- Diet, Atherogenic - blood
- Mice - blood
- Mice, Knockout - blood
- Oxidative Stress - blood
- Scavenger Receptors, Class B - genetics
- Find related publications in this database (Keywords)
- HDL cholesterol
- antioxidant enzymes
- oxidative stress
- isoprostanes
- mouse models