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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Demel, U; Tilz, GP; Foeldes-Papp, Z; Gutierrez, B; Albert, WH; Böcher, O.
Detection of tumour cells in the peripheral blood of patients with breast cancer. Development of a new sensitive and specific immunomolecular assay.
J Exp Clin Cancer Res. 2004; 23(3):465-468
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Demel Ulrike
- Co-Autor*innen der Med Uni Graz
- Földes-Papp Zeno
- Tilz Gernot
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- Abstract:
- Malignant cells in the peripheral blood of patients with solid tumours are of considerable importance for the prognosis and therapeutic correlation. Their detection however is difficult due to lack of sensitivity, specificity and technical problems in standardisation. In this original article we show a new sensitive method overcoming the hitherto known difficulties by combining traditional antibody-techniques with a RT-PCR. Due to this method 2 tumour cells within 5 ml of peripheral blood can be detected in spiking experiments.
- Find related publications in this database (using NLM MeSH Indexing)
- Breast Neoplasms - blood Breast Neoplasms - diagnosis
- Dose-Response Relationship, Drug -
- Edetic Acid - chemistry
- Humans -
- Immunoassay - methods
- Neoplastic Cells, Circulating - metabolism
- Prognosis -
- RNA, Messenger - metabolism
- Reverse Transcriptase Polymerase Chain Reaction -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- tumour cells
- peripheral blood
- immunomolecular test
- RT-PCR