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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leis, HJ; Fauler, G; Rechberger, GN; Windischhofer, W.
Electron-capture mass spectrometry: a powerful tool in biomedical trace level analysis.
CURR MEDICINAL CHEM. 2004; 11(12): 1585-1594.
Doi: 10.2174/0929867043365035
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Leis Hans-Joerg
- Co-Autor*innen der Med Uni Graz
- Fauler Günter
- Windischhofer Werner
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- Abstract:
- This review focuses on the advances in electron capture mass spectrometry. Electron-capture (EC) is a sensitive ionisation technique for mass spectrometry providing selectivity towards electrophoric compounds. Recent advances in instrumentation have led to a more widespread application of this method in biomedical and pharmaceutical analysis. After a brief introduction to EC-mass spectrometry (MS), potential targets for EC-MS analysis are defined and enhancement of sensitivity by electrophoric derivatisation is discussed. A wide range of applications is selected, including prostanoid analysis in biomedical systems (with the oxidative stress indicators isoprostanes) and the trace level analysis of endogenous low-molecular weight compounds. Application to the trace level gas chromatography-negative ion chemical ionization MS (GC-NICI-MS) analysis of complex glucuronides is also demonstrated, as well as a wide range of drugs analysed in human blood. The review should point out the versatility and unique sensitivity of the technique, making it useful for basic research in medicinal chemistry, as well as clinical diagnosis, pharmaceutical and toxicological applications.
- Find related publications in this database (using NLM MeSH Indexing)
- Chromatography, Liquid -
- Electrons -
- Gas Chromatography-Mass Spectrometry - instrumentation
- Hydrocarbons, Fluorinated - analysis
- Mass Spectrometry - instrumentation
- Spectrometry, Mass, Electrospray Ionization - instrumentation
- Find related publications in this database (Keywords)
- resonance electron capture
- mass spectrometry
- negative ion
- chemical ionisation
- dissociative electron capture
- derivatisation