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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jung, A; Krisper, P; Haditsch, B; Stauber, RE; Trauner, M; Holzer, H; Schneditz, D.
Bilirubin kinetic modeling for quantification of extracorporeal liver support.
Blood Purif. 2006; 24(4):413-422
Doi: 10.1159/000094575
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Jung Aleksandra
- Schneditz Daniel
- Co-Autor*innen der Med Uni Graz
- Holzer Herwig
- Krisper Peter
- Stauber Rudolf
- Trauner Michael
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- Abstract:
- Background/Aim: To provide a measure of treatment dose for extracorporeal liver support (ELS). Methods:The kinetics of conjugated bilirubin were described by a two-compartment model (V-c, V-p) with central elimination (K) and constant generation rate (G). The transfer of solute between compartments was modeled by intercompartmental clearance (K-pc). The central compartment (V-c) was assumed as a constant fraction of total volume (V-c = 0.3*V-t). Results: Eight patients were studied during 35 treatments lasting 6 h each. The average K, V-t, K-pc, G, and mass of conjugated bilirubin removed were 18.6 +/- 3.9 ml/min, 9.1 +/- 3.8 liters, 103 +/- 108 ml/min, 0.33 +/- 0.15 mg/min, and 641 +/- 275 mg, respectively. The reduction ratio (48 +/- 10%) measured as the change in post-to pre-treatment concentrations underestimated the modeled fraction of bilirubin mass removed (54 +/- 13%) essentially because of significant conjugated bilirubin appearance during treatments. Conclusions: Kinetic analysis provides an improved measure of treatment dose as generation, distribution, and elimination of conjugated bilirubin are jointly considered. Copyright (c) 2006 S. Karger AG, Basel
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Bilirubin - blood
- Extracorporeal Circulation - methods
- Female -
- Humans -
- Liver Failure - blood Liver Failure - therapy
- Liver, Artificial -
- Male -
- Middle Aged -
- Models, Biological -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- compartment modeling
- bilirubin generation
- parameter identification