Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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"Köpfe" der aktuellen Meldungen:

Nina Höller

Nariae Baik-Schneditz

Bernhard Schwaberger

Lukas Peter Mileder

Niels Hammer

Gerhard Pichler

Roland Malli

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Lammert, F; Wang, DQ; Hillebrandt, S; Geier, A; Fickert, P; Trauner, M; Matern, S; Paigen, B; Carey, MC.
Spontaneous cholecysto- and hepatolithiasis in Mdr2-/- mice: a model for low phospholipid-associated cholelithiasis.
Hepatology. 2004; 39(1):117-128 Doi: 10.1002/hep.20022 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz: Fickert Peter; Trauner Michael
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Abstract:: Previously, we identified needle-like and filamentous, putatively "anhydrous" cholesterol crystallization in vitro at very low phospholipid concentrations in model and native biles. Our aim now was to address whether spontaneous gallstone formation occurs in Mdr2 (Abcb4) knockout mice that are characterized by phospholipid-deficient bile. Biliary phenotypes and cholesterol crystallization sequences in fresh gallbladder biles and non-fixed liver sections were determined by direct and polarizing light microscopy. The physical chemical nature and composition of crystals and stones were determined by sucrose density centrifugation and before mass and infrared spectroscopy. Gallbladder biles of Mdr2(-/-) mice precipitate needle-like cholesterol crystals at 12 weeks of age on chow. After 15 weeks, more than 50% of Mdr2(-/-) mice develop gallbladder stones, with female mice displaying a markedly higher gallstone-susceptibility. Although gallbladder biles of Mdr2(-/-) mice contain only traces (
Find related publications in this database (using NLM MeSH Indexing): ATP-Binding Cassette Transporters - genetics; Animals -; Bile - chemistry Bile - metabolism; Bile Ducts - metabolism Bile Ducts - pathology; Cholelithiasis - metabolism Cholelithiasis - pathology Cholelithiasis - physiopathology; Cholesterol - chemistry Cholesterol - metabolism; Crystallization -; Disease Models, Animal -; Female -; Gallbladder - metabolism Gallbladder - pathology; Liver - metabolism Liver - pathology; Male -; Mice -; Mice, Inbred Strains -; Mice, Knockout -; P-Glycoproteins - genetics; Phenotype -; Phospholipids - metabolism; Sex Factors -