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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bartlett, SE; Enquist, J; Hopf, FW; Lee, JH; Gladher, F; Kharazia, V; Waldhoer, M; Mailliard, WS; Armstrong, R; Bonci, A; Whistler, JL.
Dopamine responsiveness is regulated by targeted sorting of D2 receptors.
PROC NAT ACAD SCI USA. 2005; 102: 11521-11526.
Doi: 10.1073/pnas.0502418102
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- Co-Autor*innen der Med Uni Graz
- Waldhoer Maria
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- Abstract:
- Aberrant dopaminergic signaling is a critical determinant in multiple psychiatric disorders, and in many disease states, dopamine receptor number is altered. Here we identify a molecular mechanism that selectively targets D2 receptors for degradation after their activation by dopamine. The degradative fate of D2 receptors is determined by an interaction with G protein coupled receptor-associated sorting protein (GASP). As a consequence of this GASP interaction, D2 responses in rat brain fail to resensitize after agonist treatment. Disruption of the D2-GASP interaction facilitates recovery of D2 responses, suggesting that modulation of the D2-GASP interaction is important for the functional down-regulation of D2 receptors.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain - metabolism
- Cell Line - metabolism
- Comparative Study - metabolism
- Dopamine - metabolism
- Down-Regulation - metabolism
- Electrophysiology - metabolism
- Glutathione Transferase - metabolism
- Green Fluorescent Proteins - metabolism
- Humans - metabolism
- Immunohistochemistry - metabolism
- Immunoprecipitation - metabolism
- Male - metabolism
- Rats - metabolism
- Rats, Sprague-Dawley - metabolism
- Receptors, Dopamine D2 - metabolism
- Research Support, N.I.H., Extramural - metabolism
- Research Support, Non-U.S. Gov't - metabolism
- Vesicular Transport Proteins - metabolism
- Find related publications in this database (Keywords)
- G protein-coupled receptor
- trafficking
- down-regulation
- resensitization
- degradation