Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Waldhoer, M; Bartlett, SE; Whistler, JL.
Opioid receptors.
ANNU REV BIOCHEM. 2004; 73: 953-990. Doi: 10.1146/annurev.biochem.73.011303.073940
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Waldhoer Maria
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
Opioid receptors belong to the large superfamily of seven transmembrane-spanning (7TM) G protein-coupled receptors (GPCRs). As a class, GPCRs are of fundamental physiological importance mediating the actions of the majority of known neurotransmitters and hormones. Opioid receptors are particularly intriguing members of this receptor family. They are activated both by endogenously produced opioid peptides and by exogenously administered opiate compounds, some of which are not only among the most effective analgesics known but also highly addictive drugs of abuse. A fundamental question in addiction biology is why exogenous opioid drugs, such as morphine and heroin, have a high liability for inducing tolerance, dependence, and addiction. This review focuses on many aspects of opioid receptors with the aim of gaining a greater insight into mechanisms of opioid tolerance and dependence.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Drug Tolerance - physiology
Humans - physiology
Ligands - physiology
Models, Molecular - physiology
Mutation - physiology
Phylogeny - physiology
Receptors, Opioid - chemistry
Research Support, Non-U.S. Gov't - chemistry
Research Support, U.S. Gov't, P.H.S. - chemistry
Substance Withdrawal Syndrome - etiology
Substance-Related Disorders - etiology

Find related publications in this database (Keywords)
morphine
GPCR/7TM
RAVE
tolerance
dependence
© Med Uni Graz • Impressum