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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Greilberger, J; Oettl, K; Cvirn, G; Reibnegger, G; Jürgens, G.
Modulation of LDL oxidation by 7,8-dihydroneopterin.
FREE RADICAL RES. 2004; 38: 9-17.
Doi: 10.1080%2F10715760310001623322
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Greilberger Joachim
- Co-Autor*innen der Med Uni Graz
- Cvirn Gerhard
- Jürgens Günther
- Öttl Karl
- Reibnegger Gilbert
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- Abstract:
- Human macrophages stimulated with interferon-gamma generate neopterin and 7,8-dihydroneopterin which interfere with reactive species involved in LDL oxidation. While neopterin was found to have pro-oxidative effects on copper-mediated LDL oxidation, the influence of 7,8-dihydroneopterin is more complex. This study provides detailed information that 7,8-dihydroneopterin reveals both pro-oxidative and anti-oxidative effects on copper mediated LDL oxidation. 7,8-dihydroneopterin inhibited the oxidation of native LDL effectively monitored by (i) formation of conjugated dienes, (ii) relative electrophoretic mobility (EM) and (iii) specific oxidized epitopes. Using minimally oxidized LDL (mi-LDL) or moderately oxidized LDL (mo-LDL) 7,8-dihydroneopterin changed its antioxidative behavior to a strongly pro-oxidative. Incubation of 7,8-dihydroneopterin with native LDL, mi-LDL or mo-LDL in the absence of copper ions showed that formation of conjugated dienes was more increased in mo-LDL than in mi-LDL while no diene formation was observed with native LDL. We suggest that 7,8-dihydroneopterin is a modulator for LDL oxidation in the presence of copper ions depending on the "oxidative status" of this lipoprotein.
- Find related publications in this database (using NLM MeSH Indexing)
- Chelating Agents - pharmacology
- Copper - metabolism
- Edetic Acid - pharmacology
- Electrophoretic Mobility Shift Assay - pharmacology
- Epitopes - metabolism
- Humans - metabolism
- Lipoproteins, LDL - chemistry
- Neopterin - analogs and derivatives
- Oxidants - metabolism
- Oxidation-Reduction - metabolism
- Pentetic Acid - pharmacology
- Research Support, Non-U.S. Gov't - pharmacology
- Find related publications in this database (Keywords)
- 7
- -dihydroneopterin
- lipid hydroperoxides (LPO)
- lipid peroxidation
- electrophoretic mobility (EM)
- free radicals
- atherosclerosis