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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Peskar, BM; Ehrlich, K; Egger, T; Sattler, W.
Dexamethasone impairs the gastric mucosal integrity in rats treated with a cyclooxygenase-1 but not with a cyclooxygenase-2 inhibitor.
Pharmacology. 2006; 76(4):180-184
Doi: 10.1159/000091575
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Sattler Wolfgang
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- Abstract:
- In rats, neither the cyclooxygenase-1 inhibitor SC-560 nor the cyclooxygenase-2 inhibitor rofecoxib damages the gastric mucosa. Coadministration of dexamethasone induced injury in SC-560- but not in rofecoxib-treated rats. High levels of cyclooxygenase-1 protein occurred in the gastric mucosa of control rats, with no change after administration of SC-560. In contrast, the gastric cyclooxygenase-2 protein levels were low in control rats, but increased in a time-dependent manner after administration of SC-560. Dexamethasone prevented the increase in cyclooxygenase-2 protein levels. Our findings show that inhibition of cyclooxygenase-1 upregulates cyclooxygenase-2. When the upregulation is prevented by dexamethasone, gastric damage develops, suggesting that induction of cyclooxygenase-2 represents a compensatory mechanism that counteracts the injurious effect of cyclooxygenase-1 inhibition.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Inflammatory Agents - adverse effects
- Cyclooxygenase 1 - biosynthesis
- Cyclooxygenase 2 - biosynthesis
- Cyclooxygenase 2 Inhibitors - adverse effects
- Cyclooxygenase Inhibitors - adverse effects
- Dexamethasone - adverse effects
- Drug Interactions - adverse effects
- Drug Therapy, Combination - adverse effects
- Gastric Mucosa - drug effects
- Lactones - adverse effects
- Male - adverse effects
- Pyrazoles - adverse effects
- Rats - adverse effects
- Rats, Wistar - adverse effects
- Sulfones - adverse effects
- Time Factors - adverse effects
- Find related publications in this database (Keywords)
- dexamethasone
- cyclooxygenase-1
- cyclooxygenase-2
- gastric mucosal damage
- SC-560
- rofecoxib