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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Haemmerle, G; Lass, A; Zimmermann, R; Gorkiewicz, G; Meyer, C; Rozman, J; Heldmaier, G; Maier, R; Theussl, C; Eder, S; Kratky, D; Wagner, EF; Klingenspor, M; Hoefler, G; Zechner, R.
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase.
SCIENCE. 2006; 312: 734-737.
Doi: 10.1126/science.1123965
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- Co-Autor*innen der Med Uni Graz
- Gorkiewicz Gregor
- Höfler Gerald
- Kratky Dagmar
- Maier Robert
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- Abstract:
- Fat tissue is the most important energy depot in vertebrates. The release of free fatty acids (FFAs) from stored fat requires the enzymatic activity of lipases. We showed that genetic inactivation of adipose triglyceride lipase (ATGL) in mice increases adipose mass and leads to triacylglycerol deposition in multiple tissues. ATGL-deficient mice accumulated large amounts of lipid in the heart, causing cardiac dysfunction and premature death. Defective cold adaptation indicated that the enzyme provides FFAs to fuel thermogenesis. The reduced availability of ATGL-derived FFAs leads to increased glucose use, increased glucose tolerance, and increased insulin sensitivity. These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipocytes - cytology
- Adipose Tissue - anatomy and histology
- Animals - anatomy and histology
- Blood Glucose - metabolism
- Brown Fat - enzymology
- Carboxylic Ester Hydrolases - deficiency
- Cell Size - deficiency
- Energy Metabolism - deficiency
- Fatty Acids, Nonesterified - blood
- Female - blood
- Heart Failure, Congestive - pathology
- Homeostasis - pathology
- Insulin - blood
- Isoproterenol - pharmacology
- Kidney - metabolism
- Lipase - deficiency
- Lipids - blood
- Lipolysis - drug effects
- Male - drug effects
- Mice - drug effects
- Myocardium - metabolism
- Myocytes, Cardiac - cytology
- Oxygen Consumption - cytology
- Research Support, Non-U.S. Gov't - cytology
- Testis - metabolism
- Thermogenesis - metabolism
- Triglycerides - metabolism
- Ventricular Dysfunction, Left - physiopathology