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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sundl, I; Pail, E; Mellitzer, K; Toplak, H; Winklhofer-Roob, BM.
Effects of orlistat therapy on plasma concentrations of oxygenated and hydrocarbon carotenoids
LIPIDS. 2006; 41: 113-118.
Doi: 10.1007/s11745-006-5078-6
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- Toplak Hermann
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- Abstract:
- Orlistat is a lipase inhibitor that is applied for treating obesity. Lipases are required for digestion and absorption of dietary lipids and fat-soluble vitamins and carotenoids. The aim of this study was to compare the effects of orlistat therapy on plasma concentrations of oxygenated (beta-cryptoxanthin, lutein/zeaxanthin) and hydrocarbon (alpha-, beta-carotene, lycopene) carotenoids. Six patients. with a body mass index (BMI) >= 30 kg/m(2) received 360 mg/d orlistat over 4.5 mon. Plasma carotenoid concentrations were determined at baseline (T-0) and after 3 (T-3) and 4.5 mon (T-4.5) along with anthropometric, dietary, and biochemical indices, including plasma lipids, retinol, alpha- and gamma-tocopherols, and FA. Baseline BMI was 32.7 +/- 1.97 kg/m(2). Five of six patients lost weight; the average weight loss was 3.6 +/- 2.4% (P = 0.47). There were no significant changes in dietary carotenoid intakes. In contrast, plasma alpha-and beta-carotene concentrations decreased significantly from To to T-4.5 by 45% (P = 0.006) and 32% (P = 0.013), respectively. Plasma lycopene decreased from To to T, but increased again from T-3 to T-4.5, while beta-cryptoxanthin and lutein/zeaxanthin concentrations did not change. There were no significant alterations in tocopherol, retinol, and FA concentrations. In conclusion, even though weight loss was not significant, orlistat therapy was associated with significant decreases in plasma concentrations of the highly lipophilic hydrocarbon carotenoids, alpha- and beta-carotene.