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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gurakuqi, GC; Stadlbauer, V; Stepan, V; Warnkross, H; Trauner, M.
Addison's disease as a rare cause of chronically elevated liver enzymes].
Z Gastroenterol. 2006; 44(2):179-183
Doi: 10.1055/s-2005-858976
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Gurakuqi Gerald
- Co-Autor*innen der Med Uni Graz
- Stadlbauer-Köllner Vanessa
- Stepan Vinzenz
- Trauner Michael
- Warnkroß Helga
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- Abstract:
- Common causes of chronically elevated serum liver enzymes include fatty liver disease, chronic viral hepatitis, autoimmune hepatitis, or hereditary metabolic disorders. Adrenocortical insufficiency can also cause elevated liver enzymes. Since 1990 only 11 cases have been reported. We here report a 52-year-old man with elevated liver enzymes (1.5 x upper limit of normal) over the past 10 years. Furthermore, hyponatremia and hyperkalemia were noted. He complained of fatigue and low blood pressure over the past few years. At physical examination a dark complexion was noted. After ruling out chronic viral hepatitis, autoimmune disease, metabolic or hereditary disorders, rare causes of elevated liver enzymes were considered. The endocrinological work-up revealed Addison's disease as cause of serum electrolyte disturbance and elevated liver enzymes. The patient was successfully treated with hydrocortisol and fludrocortisol. After one week, liver enzymes, serum electrolytes and arterial blood pressure had normalized. In conclusion, for patients with constantly elevated liver enzymes also rare, extrahepatic diseases have to be considered. Addison's disease is a rare but fully reversible cause for elevated liver enzymes.
- Find related publications in this database (using NLM MeSH Indexing)
- Addison Disease - complications Addison Disease - diagnosis Addison Disease - drug therapy Addison Disease - enzymology
- Fludrocortisone - therapeutic use
- Humans -
- Hydrocortisone - therapeutic use
- Liver - enzymology
- Liver Diseases - diagnosis Liver Diseases - drug therapy Liver Diseases - enzymology Liver Diseases - etiology
- Male -
- Middle Aged -
- Rare Diseases - complications Rare Diseases - diagnosis Rare Diseases - drug therapy Rare Diseases - enzymology
- Treatment Outcome -
- Find related publications in this database (Keywords)
- liver
- Addison's disease
- adrenocortical insufficiency
- elevated liver enzymes