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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lakio, L; Lehto, M; Tuomainen, AM; Jauhiainen, M; Malle, E; Asikainen, S; Pussinen, PJ.
Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans.
J ENDOTOXIN RES. 2006; 12(1): 57-64.
Doi: 10.1179/096805106X89099
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- Co-Autor*innen der Med Uni Graz
- Malle Ernst
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- Abstract:
- An association between cardiovascular and periodontal disease may be due to lipopolysaccharide (LPS)-promoted release of inflammatory mediators, adverse alterations of the lipoprotein profile, and an imbalance in cholesterol homeostasis. Since periodontopathogenic potential differs between serotypes of a major periodontal pathogen, Actinobacillus actinomycetemcomitans, we studied the pro-atherogenic properties of LPS preparations from serotypes b and d strains on macrophages (RAW 264.7). A. actinomycetemcomitans LPS preparations induced a time-dependent release of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). LPS induced foam cell formation and cholesteryl ester accumulation from native low density lipoprotein in the following order: A. actinomycetemcomitans strains JP2 (serotype b) > Y4 (serotype b) > IDH781 (serotype d). mRNA expression levels of scavenger receptor class B, type-I, and ATP-binding cassette transporter-1, receptors mediating cholesterol efflux from macrophages, were decreased by LPS preparations. The results suggest that the pro-atherogenic potential of A. actinomycetemcomitans LPS may depend on the infecting strain and correlate with the periodontopathogenic potential of the pathogen.
- Find related publications in this database (using NLM MeSH Indexing)
- ATP-Binding Cassette Transporters - metabolism
- Actinobacillus actinomycetemcomitans - chemistry
- Animals - chemistry
- Atherosclerosis - chemically induced
- Cell Line - chemically induced
- Cholesterol, HDL - metabolism
- Cholesterol, LDL - metabolism
- Cytokines - biosynthesis
- Foam Cells - drug effects
- Lipid Metabolism - drug effects
- Lipopolysaccharides - chemistry
- Macrophages - drug effects
- Mice - drug effects
- Periodontal Diseases - microbiology
- RNA - biosynthesis
- Reverse Transcriptase Polymerase Chain Reaction - biosynthesis
- Scavenger Receptors, Class B - biosynthesis
- Find related publications in this database (Keywords)
- foam cell formation
- infection
- inflammation
- periodontitis
- RAW 264.7 macrophages
- SR-BI
- ABCA-1