Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Navigation/Suche
- Forscher*innen
- Institutionen
- Projekte
- Publikationen
- Partner
- Geldgeber
- Ausstattung
- Knowhow
- Forschungsfelder
"Köpfe" der aktuellen Meldungen:
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ellis, E; Wagner, M; Lammert, F; Nemeth, A; Gumhold, J; Strassburg, CP; Kylander, C; Katsika, D; Trauner, M; Einarsson, C; Marschall, HU.
Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin.
J HEPATOL. 2006; 44(1): 243-245.
Doi: 10.1016/j.jhep.2005.09.011
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Sommer Judith
- Trauner Michael
- Wagner Martin
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- We report two patients with uncommon Gilbert's syndrome with severe unconjugated hyperbilirubinemia which was reduced from 200 to 60-90 micromol/L by long-term administration of rifampicin. Hepatic induction of bilirubin-glucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Bilirubin - blood
- Cells, Cultured -
- Enzyme Inhibitors - therapeutic use
- Female -
- Follow-Up Studies -
- Gilbert Disease - blood Gilbert Disease - drug therapy Gilbert Disease - pathology
- Glucuronosyltransferase - antagonists & inhibitors Glucuronosyltransferase - blood
- Hepatocytes - pathology
- Humans -
- Male -
- Rifampin - therapeutic use
- Time Factors -
- Find related publications in this database (Keywords)
- Gilbert
- jaundice
- glucuronosyltransferase
- cultured human hepatocytes