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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Lange, B; Brehm, TT; Arend, SM; Arias-Guillén, M; Bakker, M; Berastegui, C; Babiker, M; Charif, R; Duarte, R; Flick, H; Hofland, RW; Ismail, J; Kniepeiss, D; Krepel, J; Krishnan, N; Kuijpers, DL; Kunst, H; van, Leth, F; Lezaic, V; Los-Arcos, I; Machová, J; Milburn, H; Morais, SA; Kon, OM; Osoro-Suarez, C; Pessegueiro, Miranda, H; Pesut, D; Rahman, A; Reischig, T; Sánchez-Montalvá, A; Spohn, HE; Stegenga, MT; de, Vries, APJ; Wagner, D; Wobser, R; Lange, C; Sester, M.
Tuberculosis incidence in solid organ transplant recipients in Europe: A multicenter TBnet cohort study.
J Infect. 2025; 92(1): 106668 Doi: 10.1016/j.jinf.2025.106668
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Co-Autor*innen der Med Uni Graz
Flick Holger
Kniepeiss Daniela
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Abstract:
BACKGROUND: Solid organ transplant (SOT) recipients face elevated tuberculosis risk, yet optimal prevention strategies in low- to medium-incidence regions remain unclear. METHODS: We conducted a multicenter retrospective cohort study of adult SOT recipients transplanted between 2007 and 2012 at 15 European centers, with follow-up through 2018. The primary outcome was microbiologically confirmed post-transplant tuberculosis. Incidence rates were calculated per 100,000 person-years; standardized incidence ratios (SIRs) used World Health Organization country-specific background rates. Cox models assessed risk factors. RESULTS: Among 5805 patients (median age 51; 62.7% male; 73.9% renal transplants), 33.8% were tested for tuberculosis infection and 10.3% received tuberculosis preventive therapy (TPT). Over 33,785 person-years, 23 patients (0.4%) developed tuberculosis (68.0/100,000 person-years). Highest incidence occurred in patients with positive screening but no TPT (233.8/100,000). Incidence was higher in Southern vs. Central Europe (251.9 vs. 28.7/100,000), with pooled SIRs of 12.8 and 3.1, respectively. Tuberculosis risk was elevated among Southern European recipients (HR 22.9) and those with migration history (HR 2.7). CONCLUSION: Tuberculosis risk is increased in European SOT recipients. Regionally adapted prevention strategies, including targeted screening in low-incidence areas and universal screening in higher-incidence regions, are warranted.

Find related publications in this database (Keywords)
IGRA
Tuberculosis
Transplantation
Progression to tuberculosis
TBnet
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