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"Faces" of the day:

Katarina Vizar Cisarova

Julia Mader

Kathrin Eller

Nadia Dandachi

Philipp Bosch

Othmar Moser

Sebastian Vosberg

Michael Dengler

Rainer Schindl

Philipp Jost

Daniel Scherr

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Hanberg, JS; Zhang, Y; Kronbichler, A; Matyjek, A; McAlear, C; Odler, B; Uchida, L; Geetha, D; Hawley, C; Jayne, D; Walsh, M; Merkel, PA; Wallace, ZS, , PEXIVAS, investigators.
Longitudinal Trajectories of Kidney Function in Patients with Severe Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Clin J Am Soc Nephrol. 2025; Doi: 10.2215/CJN.0000000881
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Odler Balazs
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Abstract:: OBJECTIVE: ANCA-associated vasculitis (AAV) causes glomerulonephritis culminating in a spectrum of chronic (CKD) and end-stage kidney disease (ESKD). Kidney function trajectories with differing CKD risk were reported in a single-center study. We sought to confirm these findings in the Plasma Exchange and Glucocorticoids in Severe AAV (PEXIVAS) trial cohort. METHODS: This cohort study included patients from PEXIVAS with a baseline and one or more estimated glomerular filtration rate (eGFR) measurements over 36 months to identify groups with similar longitudinal change in kidney function using group-based trajectory analysis. We evaluated factors associated with group membership using multivariable-adjusted multinomial logistic regression. RESULTS: We identified four trajectory groups among 663 patients: Early ESKD (113, 17%); Stable Impairment (400, 60%); Impaired with Improvement (131, 20%); Marked Improvement (19, 3%). ESKD occurred in 137 patients (21%): 113 (100%) in the Early ESKD, 23 (6%) in the Stable Impairment, and one (1%) in the Impaired with Improvement groups. Older baseline age (aOR=0.97 per one year, 95%CI 0.95-0.99), female sex (aOR=0.54, 95%CI 0.31-0.94), and baseline eGFR (aOR=0.93 per 1 mL/min/1.73 m2 increase, 95%CI 0.88-0.99) were associated with lower odds of Early ESKD vs Impaired with Improvement membership. MPO-ANCA+ (aOR=2.35, 95%CI 1.33-4.16) and hypertension (aOR=2.50, 95%CI 1.33-4.69) were associated with higher odds of Early ESKD membership. CONCLUSIONS: We identified four kidney function trajectories in AAV associated with varied risk of ESKD and CKD; male sex, MPO-ANCA specificity, baseline hypertension and lower baseline eGFR were associated with adverse kidney function trajectory. Differences in baseline characteristics identify potential targets for personalized care.
Find related publications in this database (Keywords): ANCA; clinical epidemiology; epidemiology and outcomes; vasculitis