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"Faces" of the day:

Klara Konstanze Pohl

Federica Piani

Cara Lavinia Shirin Rech

Kathrin Eller

Christine Moissl-Eichinger

Dajie Marschik

Eleonore Fröhlich

Konstantin Adrian Klötzer

Florian Moik

Marco Eigenfeld

Mahmoud Abdellatif

Benjamin Gottschalk

Christian Diener

Peter Marschik

Simon Sedej

Sascha Ahyai

Roland Malli

Wolfgang Graier

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Myronenko, O; Curcic, P; Douschan, P; Zeder, K; John, T; Suessner, S; Hoetzenecker, K; Kovacs, G; Olschewski, A; Olschewski, H; Foris, V.
Soluble Transferrin Receptor-1 in Pulmonary Hypertension Associated with COPD.
Lung. 2025; 203(1): 79 Doi: 10.1007/s00408-025-00833-3 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Foris Vasile; Myronenko Oleh; Olschewski Horst
Co-authors Med Uni Graz: Curcic Pero; Douschan Philipp; John Teresa; Kovacs Gabor; Olschewski Andrea; Zeder Katarina Eleonora
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Abstract:: PURPOSE: The pulmonary vascular involvement of COPD ranges from severe airway obstruction without pulmonary hypertension (PH) to mild airway obstruction with severe PH. Iron-dependent molecular regulators like hypoxia-inducible factor-2 (HIF-2) may contribute to these phenotypic variations. We explored the role of soluble transferrin receptor-1 (sTfR1) for diagnosis and prognosis of PH associated with COPD. METHODS: We analyzed COPD outpatients who underwent right heart catheterization and performed unsupervised clustering analysis based on sTfR1 levels and non-invasive clinical parameters to identify specific COPD phenotypes. Additionally, we examined explanted end-stage COPD lungs for TfR1 expression and iron deposition. RESULTS: sTfR1 was associated with mean pulmonary artery pressure (mPAP) (r = 0.45, p < 0.001), pulmonary vascular resistance (PVR) (r = 0.395, p < 0.001) and poor survival. sTfR1 predicted severe PH (AUROC [95% CI], 0.72 [0.61-0.83]), and AUROC was further improved based on a combination of sTfR1 and low hemoglobin (0.82 [0.73-0.92]). sTfR1-based cluster analysis distinguished three COPD phenotypes with significantly different survival. One of the two clusters with poor survival was characterized by moderate airway obstruction and moderate PH but elevated sTfR1, anemia and inflammation. In explanted COPD lungs, TfR1-positive and iron-laden cells, most likely, consisted of macrophages, and iron-loaded cell density was negatively correlated with mPAP in patients with moderate/severe PH (r = - 0.681, p = 0.015). CONCLUSIONS: Elevated sTfR1 predicts poor prognosis in patients with COPD and, particularly in combination with low hemoglobin, may serve as a biomarker for severe PH in COPD, identifying a distinct phenotype with systemic inflammation, anemia and iron deficiency.
Find related publications in this database (using NLM MeSH Indexing): Humans - administration & dosage; Pulmonary Disease, Chronic Obstructive - complications, physiopathology, blood, mortality, metabolism, diagnosis; Male - administration & dosage; Female - administration & dosage; Receptors, Transferrin - blood, metabolism; Middle Aged - administration & dosage; Aged - administration & dosage; Hypertension, Pulmonary - etiology, physiopathology, diagnosis, blood, metabolism; Antigens, CD - metabolism, blood; Prognosis - administration & dosage; Iron - metabolism; Biomarkers - blood; Lung - metabolism; Phenotype - administration & dosage; Severity of Illness Index - administration & dosage; Vascular Resistance - administration & dosage; Cardiac Catheterization - administration & dosage
Find related publications in this database (Keywords): Biomarker; Pulmonary hypertension; COPD; Iron; Soluble transferrin receptor-1