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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Woltsche, J; Pacher-Deutsch, C; Fürst, S; Gulden, L; Schwarzl, J; Feldbacher, N; Nepel, M; Celcer, L; Hasl, N; Rieper, V; Stadlbauer, V; Horvath, A.
Microbial Dysbiosis in the Urinary Microbiome of Patients with Cirrhosis.
Am J Gastroenterol. 2025;
Doi: 10.14309/ajg.0000000000003634
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Pacher-Deutsch Christian
- Stadlbauer-Köllner Vanessa
- Woltsche Johannes Nikolaus
- Co-authors Med Uni Graz
- Fürst Stefan
- Gulden Lukas Michael
- Hasl Natalie
- Horvath Angela
- Nepel Maximilian
- Rebol Lavra
- Rieper Victoria
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- Abstract:
- INTRODUCTION: Cirrhosis is associated with microbiome alterations beyond the gut, including skin, saliva, and serum. This study investigated the urinary microbiome (UMB) in patients with cirrhosis, who have an increased risk of urinary tract infections (UTIs). METHODS: Midstream urine from 137 patients was analysed via 16S rRNA sequencing; 68 patients with cirrhosis and 32 non-cirrhotic controls met inclusion criteria. RESULTS: Patients with cirrhosis showed significantly reduced alpha-diversity. The UMB of controls was enriched in Streptococcus species. DISCUSSION: Reduced microbial diversity and lower Streptococcus abundance in patients with cirrhosis might help to explain their heightened susceptibility to UTIs.