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SHR Neuro Cancer Cardio Lipid Metab Microb
Mörkl, S; Narrath, M; Schlotmann, D; Sallmutter, MT; Putz, J; Lang, J; Brandstätter, A; Pilz, R; Karl, Lackner, H; Goswami, N; Steuber, B; Tatzer, J; Lackner, S; Holasek, S; Painold, A; Jauk, E; Wenninger, J; Horvath, A; Spicher, N; Barth, A; Butler, MI; Wagner-Skacel, J.
Multi-species probiotic supplement enhances vagal nerve function - results of a randomized controlled trial in patients with depression and healthy controls.
Gut Microbes. 2025; 17(1):2492377
Doi: 10.1080/19490976.2025.2492377
[OPEN ACCESS]
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Lackner Sonja
- Leal Garcia Sabrina
- Co-authors Med Uni Graz
- Brandstätter Andreas
- Goswami Nandu
- Holasek Sandra Johanna
- Horvath Angela
- Jauk Emanuel
- Lackner Helmut Karl
- Painold Annamaria
- Pilz Rene
- Steuber Bianca
- Wagner-Skacel Jolana
- Wenninger Julian
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- Abstract:
- Major depression (MD) significantly impacts individual well-being and society. The vagus nerve plays a pivotal role in the gut-brain axis, facilitating bidirectional communication between these systems. Recent meta-analyses suggest potential antidepressant effects of probiotics, although their mechanisms remain unclear. This study aimed to assess the impact of a multi-species probiotic (OMNi-BiOTiC® STRESS Repair) on vagus nerve function in 43 MD patients and 43 healthy controls (HC). Participants received either probiotics or placebo twice daily. Serum and stool samples were collected at baseline, 7 days, 28 days, and 3 months. Vagus nerve (VN) function was evaluated using 24-hour electrocardiography (ECG) for heart rate variability (HRV), alongside stool microbiome analysis via 16S rRNA sequencing. After 3 months, MD patients receiving probiotics demonstrated significantly improved morning VN function compared to HC. MD participants who were in the probiotic group showed a significant increase in Christensellales, particularly Akkermansia muciniphila along with improved sleep parameters (use of sleep medication, sleep latency) as measured by the Pittsburgh Sleep Quality Inventory (PSI). This study highlights potential physiological benefits of probiotics in MD, potentially mediated through VN stimulation. Understanding these mechanisms could lead to novel therapeutic approaches for MD management.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Probiotics - administration & dosage
- Male - administration & dosage
- Female - administration & dosage
- Vagus Nerve - drug effects, physiopathology, physiology
- Gastrointestinal Microbiome - drug effects
- Adult - administration & dosage
- Middle Aged - administration & dosage
- Feces - microbiology
- Depressive Disorder, Major - physiopathology, microbiology, drug therapy
- Dietary Supplements - administration & dosage
- Heart Rate - drug effects
- Bacteria - classification, genetics, isolation & purification
- Akkermansia - administration & dosage
- Find related publications in this database (Keywords)
- Vagus nerve
- probiotic
- depression
- heart rate variability
- gut microbiome