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Oulhaj, A; Suliman, A; Bentaleb, M; Abdulrahman, M; Bentoumi, R; Sharp, SJ; Sourij, H.
The association between visit-to-visit variability in risk factors and incident CVD: A Post-hoc analysis of the Multi-Ethnic Study of Atherosclerosis.
Am J Epidemiol. 2025; Doi: 10.1093/aje/kwaf082
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Co-Autor*innen der Med Uni Graz
Sourij Harald
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Abstract:
Our aim is to investigate the association between visit-to-visit variability of nine risk factors and incident cardiovascular disease (CVD) in a large multi-ethnic population cohort study. We used the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. We included individuals with no previous history of CVD, with at least three repeated measurements on each risk factor including total cholesterol, HDL, LDL, non-HDL, triglyceride, Chol/HDL ratio, Diastolic Blood Pressure (DBP), Systolic Blood Pressure (DBP), and Body mass index (BMI). Visit-to-visit variability was estimated via the variability independent of the mean (VIM). A Cox proportional hazards model was used to estimate the association between visit-to-visit variability and the hazard of developing CVD. There was a statistically significant association between visit-to-visit variability in SBP, BMI, HDL and the rate of incident CVD. This rate was higher in individuals with high visit-to-visit variability for SBP [HR: 1.28, 95% CI: 1.01-1.63, P = 0.04]; BMI [HR: 1.58, 95% CI: 1.25-2.00, P < 0.001]; and HDL [HR: 1.3, 95% CI: 1.03-1.65, P = 0.025], compared to those with low visit to-visit variability. Our findings suggest that visit-to-visit variability in some CVD risk factors could be independently associated with incident CVD and may be useful to clinicians in risk stratification.

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