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Dettling, A; Kellner, C; Sundermeyer, J; Beer, BN; Besch, L; Bertoldi, LF; Blankenberg, S; Dauw, J; Eckner, D; Eitel, I; Graf, T; Horn, P; Jozwiak-Nozdrzykowska, J; Kirchhof, P; Kluge, S; Krais, J; von, Lewinski, D; Linke, A; Luedike, P; Lüsebrink, E; Nordbeck, P; Pappalardo, F; Pauschinger, M; Proudfoot, A; Rassaf, T; Reichenspurner, H; Sag, CM; Scherer, C; Schulze, PC; Schwinger, RHG; Skurk, C; Sramko, M; Tavazzi, G; Thiele, H; Morici, N; Winzer, EB; Westermann, D; Schrage, B; Mangner, N.
Incidence and predictors of weaning failure from veno-arterial extracorporeal membrane oxygenation therapy in patients with cardiogenic shock.
Eur J Heart Fail. 2025; Doi: 10.1002/ejhf.3583
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von Lewinski Dirk
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Abstract:
AIMS: This study aimed to investigate incidence and predictors of weaning failure and in-hospital death after successful weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS). METHODS AND RESULTS: Overall, 685 patients with CS treated with VA-ECMO from 23 tertiary care centres in 7 countries were analysed (median age 57 [interquartile range 49-66] years, 542 [79.1%] male, median lactate 7.6 [interquartile range 4.1-12.7] mmol/L). The cause of CS was acute myocardial infarction in 438 (63.9%) patients, and 431 (62.9%) patients presented with cardiac arrest. A total of 410 patients (59.9%) were successfully weaned from VA-ECMO, whereas in 275 patients (40.1%) weaning failed (i.e. patients died on or within 48 h after VA-ECMO support). Of the successfully weaned patients, 150 (36.6%) died before hospital discharge. On multivariable logistic regression, predictors for both patient groups varied: age (per 10 years, odds ratio [OR] 1.49, 95% confidence interval [CI] 1.25-1.76; p < 0.001) and cardiac arrest before VA-ECMO implantation (OR 1.64, 95% CI 1.01-2.64; p = 0.04) were associated with weaning failure, whereas lactate clearance within 24 h after VA-ECMO initiation was associated with successful weaning (OR 0.21, 95% CI 0.1-0.44; p < 0.001). In-hospital death after successful weaning was more likely with higher age (per 10 years, OR 1.56, 95% CI 1.24-1.97; p < 0.001), renal replacement therapy (OR 2.56, 95% CI 1.4-4.68; p = 0.002) and bleeding events (OR 2.93, 95% CI 1.4-6.14; p = 0.004). CONCLUSION: Weaning from VA-ECMO fails in 40% of patients treated with VA-ECMO for CS. When successful, survival after VA-ECMO weaning mostly depends on age and the incidence of device- and shock-related complications.

Find related publications in this database (Keywords)
Cardiogenic shock
Mechanical circulatory support
Veno-arterial extracorporeal membrane oxygenation
Weaning
Mortality
Predictors
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