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SHR Neuro Cancer Cardio Lipid Metab Microb
Amiel, T; Srinivasan, S; Turrina, C; Ebel, F; Straub, M; Schwaminger, SP.
Harnessing magnetism: evaluation of safety, tolerance and feasibility of magnetic kidney stone retrieval in vivo in porcine models.
Urolithiasis. 2024; 53(1): 12
Doi: 10.1007/s00240-024-01684-y
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- Leading authors Med Uni Graz
- Schwaminger Sebastian
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- Abstract:
- The primary objective of urolithiasis therapy is complete stone removal and highest stone-clearance rates possible to minimize recurrence. A novel approach that employs a magnetic suspension and a magnetic probe for the passive collection and removal of small residual fragments was developed. This study assessed the feasibility of this system in porcine models. Five female domestic pigs underwent retrograde intrarenal surgery under general anaesthesia to assess the new magnetic system. Pre-analysed human calculi were endoscopically inserted and comminuted using lithotripsy. The magnetic suspension was applied, and the magnetic-stone fragment complex was extracted. After nephrectomy, independent blinded pathologists evaluated all the kidneys. Safety and tolerance assessments revealed no adverse events (i.e. no complications on the Clavien-Dindo scale > 1) or complications associated with treatment. This study revealed superficial urothelial damage in all animals, characterized by desquamation and inflammation, caused primarily by the insertion of access sheaths and laser lithotripsy. Residual magnetic particles were observed in the renal pelvis but did not show signs of toxicity even though this study is limited to the acute treatment. No pathological indicators were observed in the hemogram and urinalysis. Overall, the treatment did not cause any significant pathological changes. Preclinical in vivo evaluation of magnetic extraction of small rest fragments in porcine kidneys presents a promising, atraumatic approach for fragments removal. It demonstrated safety, tolerance, and feasibility that warrants clinical investigation. This method has the potential to increase stone-clearance rates with shorter extraction times, offering a possibility for addressing the challenge of urolithiasis in clinical practice.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Kidney Calculi - surgery, therapy, pathology
- Feasibility Studies - administration & dosage
- Female - administration & dosage
- Swine - administration & dosage
- Disease Models, Animal - administration & dosage
- Magnetics - administration & dosage
- Lithotripsy - adverse effects, methods, instrumentation
- Kidney - pathology, surgery
- Humans - administration & dosage
- Find related publications in this database (Keywords)
- Kidney stone removal
- Magnetic particles
- Magnetic extraction
- Calculi
- Porcine model
- Lithotripsy