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SHR Neuro Cancer Cardio Lipid Metab Microb
Zeder, K; Sassmann, T; Foris, V; Douschan, P; Olschewski, H; Kovacs, G.
Severe pulmonary hypertension in chronic obstructive pulmonary disease - From clinical perspective to histological evidence
INT J CARDIOL CONGEN. 2024; 17: 100519
Doi: 10.1016/j.ijcchd.2024.100519
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Zeder Katarina Eleonora
- Co-authors Med Uni Graz
- Douschan Philipp
- Foris Vasile
- John Teresa
- Kovacs Gabor
- Olschewski Horst
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- Abstract:
- Severe pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) is currently defined by an elevated mean pulmonary arterial pressure and strongly elevated pulmonary vascular resistance >5 wood units. Clinically, these patients show a male predominance, and usually present with very severe dyspnea, severe hypoxemia, strongly decreased exercise capacity and poor prognosis, even though the clinical picture is frequently associated with less severe airflow obstruction. Explanted lung samples of patients with COPD and severe PH show severe remodeling of small pulmonary arterioles, predominantly in the intima and media of the vessels. In this concise review, we discuss the clinical and histopathological evidence of severe PH in COPD.
- Find related publications in this database (Keywords)
- Pulmonary hypertension
- Chronic obstructive pulmonary disease
- Remodeling
- Diagnosis
- Survival