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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Gressenberger, P; Posch, F; Adelsmayr, G; Nagy, E; Kaufmann-Bühler, AK; Steiner, J; Janisch, M; Reiter, C; Eibisberger, M; Janek, E; Softic, N; Fuchsjäger, M; Gütl, K; Jud, P; Silbernagel, G; Raggam, RB; Brodmann, M; Gary, T; Schmid, J.
Lipoprotein (a) is not associated with thrombus burden derived from CT pulmonary angiography in patients with acute pulmonary embolism.
Sci Rep. 2024; 14(1): 25962 Doi: 10.1038/s41598-024-77669-z [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Adelsmayr Gabriel
Gressenberger Paul Georg
Schmid Johannes
Co-Autor*innen der Med Uni Graz
Brodmann Marianne
Eibisberger Martin
Fuchsjäger Michael
Gary Thomas
Janek Elmar
Janisch Michael August Johann
Jud Philipp
Kaufmann-Bühler Ann-Katrin
Kurzmann-Gütl Katharina
Nagy Eszter
Posch Florian
Raggam Reinhard Bernd
Reiter Clemens
Silbernagel Günther
Softic Nina
Steiner Jakob
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Abstract:
Lipoprotein (a) [Lp(a)] is suspected to have antifibrinolytic effects, however, its relevance for the severity of venous thromboembolic events remains unclear. We studied the association of Lp(a) levels with thrombus load in pulmonary embolism (PE). 90 patients (40% female, median age 70 [56-79] years) at our tertiary care hospital with a diagnosis of acute PE, available Lp(a) levels and CT pulmonary angiography (CT-PA) performed between April 2017 and December 2019 were included. All CT-PA scans were reanalyzed and thrombus load was determined via Qanadli CT obstruction index (CTOI) and most proximal thrombus location. Median Lp(a) levels were 11.4 [9.3-29.1] mg/dL, median D-dimer levels were 4.6 [2.1-9.8] mg/L, median CTOI was 23 [8-50], central PE was present in 27 (30%) patients. Lp(a) did not correlate with CTOI (r = 0.02, p = 0.922) and was not associated with thrombus location (p = 0.369). CTOI significantly correlated with D-dimer (r = 0.43, p < 0.001) and right to left ventricular diameter ratio (r=-0.49, p = < 0.001). Our findings showed that Lp(a) is not associated with thrombus burden in PE, which suggests that a relevant effect of Lp(a) on the extent of venous thromboembolism is unlikely.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Pulmonary Embolism - diagnostic imaging, blood
Female - administration & dosage
Male - administration & dosage
Middle Aged - administration & dosage
Computed Tomography Angiography - methods
Aged - administration & dosage
Lipoprotein(a) - blood
Thrombosis - diagnostic imaging
Fibrin Fibrinogen Degradation Products - analysis, metabolism
Acute Disease - administration & dosage
Retrospective Studies - administration & dosage

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