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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Duller, S; Moissl-Eichinger, C.
Archaea in the Human Microbiome and Potential Effects on Human Infectious Disease
EMERG INFECT DIS. 2024; 30(8):
Doi: 10.3201/eid3008.240181
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Duller Stefanie
- Moissl-Eichinger Christine
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- Abstract:
- Archaea represent a separate domain of life, next to bacteria and eukarya. As components of the human mi-crobiome, archaea have been associated with various diseases, including periodontitis, endodontic infections, small intestinal bacterial overgrowth, and urogenital tract infections. Archaea are generally considered nonpatho-genic; the reasons are speculative because of limited knowledge and gene annotation challenges. Neverthe-less, archaeal syntrophic principles that shape global mi-crobial networks aid both archaea and potentially patho-genic bacteria. Evaluating archaea interactions remains challenging, requiring clinical studies on inflammatory potential and the effects of archaeal metabolism. Es-tablishing a culture collection is crucial for investigating archaea functions within the human microbiome, which could improve health outcomes in infectious diseases. We summarize potential reasons for archaeal nonpatho-genicity, assess the association with infectious diseases in humans, and discuss the necessary experimental steps to enable mechanistic studies involving archaea.