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SHR Neuro Cancer Cardio Lipid Metab Microb
Oulhaj, A; Aziz, F; Suliman, A; Eller, K; Bentoumi, R; Buse, JB; Al, Mahmeed, W; von, Lewinski, D; Coleman, RL; Holman, RR; Sourij, H.
Estimated glomerular filtration rate slope and risk of primary and secondary major adverse cardiovascular events and heart failure hospitalization in people with type 2 diabetes: An analysis of the EXSCEL trial.
Diabetes Obes Metab. 2024; 26(10): 4602-4612.
Doi: 10.1111/dom.15817
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Sourij Harald
- Co-authors Med Uni Graz
- Aziz Faisal
- Eller Kathrin
- von Lewinski Dirk
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- Abstract:
- AIM: The decline in estimated glomerular filtration rate (eGFR), a significant predictor of cardiovascular disease (CVD), occurs heterogeneously in people with diabetes because of various risk factors. We investigated the role of eGFR decline in predicting CVD events in people with type 2 diabetes in both primary and secondary CVD prevention settings. MATERIALS AND METHODS: Bayesian joint modelling of repeated measures of eGFR and time to CVD event was applied to the Exenatide Study of Cardiovascular Event Lowering (EXSCEL) trial to examine the association between the eGFR slope and the incidence of major adverse CV event/hospitalization for heart failure (MACE/hHF) (non-fatal myocardial infarction, non-fatal stroke, CV death, or hospitalization for heart failure). The analysis was adjusted for age, sex, smoking, systolic blood pressure, baseline eGFR, antihypertensive and lipid-lowering medication, diabetes duration, atrial fibrillation, high-density cholesterol, total cholesterol, HbA1c and treatment allocation (once-weekly exenatide or placebo). RESULTS: Data from 11 101 trial participants with (n = 7942) and without (n = 3159) previous history of CVD were analysed. The mean ± SD eGFR slope per year in participants without and with previous CVD was -0.68 ± 1.67 and -1.03 ± 2.13 mL/min/1.73 m2, respectively. The 5-year MACE/hHF incidences were 7.5% (95% CI 6.2, 8.8) and 20% (95% CI 19, 22), respectively. The 1-SD decrease in the eGFR slope was associated with increased MACE/hHF risks of 48% (HR 1.48, 95% CI 1.12, 1.98, p = 0.007) and 33% (HR 1.33, 95% CI 1.18,1.51, p < 0.001) in participants without and with previous CVD, respectively. CONCLUSIONS: eGFR trajectories over time significantly predict incident MACE/hHF events in people with type 2 diabetes with and without existing CVD, with a higher hazard ratio for MACE/hHF in the latter group.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Diabetes Mellitus, Type 2 - complications, drug therapy
- Male - administration & dosage
- Female - administration & dosage
- Glomerular Filtration Rate - administration & dosage
- Heart Failure - epidemiology, complications, physiopathology
- Middle Aged - administration & dosage
- Hospitalization - statistics & numerical data
- Aged - administration & dosage
- Cardiovascular Diseases - epidemiology, etiology, prevention & control
- Hypoglycemic Agents - therapeutic use
- Risk Factors - administration & dosage
- Incidence - administration & dosage
- Diabetic Angiopathies - epidemiology, prevention & control
- Exenatide - therapeutic use
- Bayes Theorem - administration & dosage
- Secondary Prevention - methods
- Find related publications in this database (Keywords)
- cardiovascular disease
- estimated glomerular filtration rate
- heart failure hospitalization
- major adverse cardiovascular events
- type 2 diabetes