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Reiter, C; Puseljic, M; Fuchsjäger, M; Schmid, J.
Estimating synthetic hematocrit and extracellular volume from native blood pool T1 times at 3 Tesla CMR: Derivation of a conversion equation, accuracy and comparison with published formulas.
Eur J Radiol. 2024; 178:111659 Doi: 10.1016/j.ejrad.2024.111659
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Führende Autor*innen der Med Uni Graz
Puseljic Marijan
Reiter Clemens
Schmid Johannes
Co-Autor*innen der Med Uni Graz
Fuchsjäger Michael
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Abstract:
PURPOSE: Calculation of extracellular volume fraction (ECV), a marker of myocardial fibrosis in cardiac magnetic resonance imaging (CMR), requires hematocrit (Hct). We aimed to correlate Hct levels with native blood T1 times, to derive a formula for estimating synthetic Hct (Hctsyn) and synthetic ECV (ECVsyn), to assess accuracy of ECVsyn and to compare our model with published formulas. METHOD: In this retrospective study, a cohort of 250 CMR scans with T1 mapping (3T, MOLLI 5(3)3, endsystolic aquisition), was divided into a derivation and validation cohort. Native T1 times of the left ventricular blood pool (T1native,midLV) were correlated with Hct levels from blood sampling within 24 h (Hct24h) and a formula for calculation of Hctsyn was derived by linear regression. RESULTS: In the derivation cohort (n = 167), Hct24h showed a good association with T1native,midLV (r = -0.711, p < 0.001). The resulting regression equation was Hctsyn = 1/T1native,midLV * 1355.52-0.310. In the validation cohort (n = 83), Hctsyn and Hct24h showed good correlation (r = 0.726, p < 0.001), while ECVsyn, and ECV24h demonstrated excellent correlation (r = 0.940, p < 0.001). ECVsyn had a minimal bias of 0.28 % and the misclassification rate (8.8 %) was comparable to the variability introduced by repeated Hct measurements (misclassification in 7.5 %). Applying published formulas in our cohort resulted in incorrect classification in up to 60 %. CONCLUSION: We provide a formula for estimating Hctsyn from native blood T1 on a 3T scanner. The measurement error of ECVsyn is low and comparable to the error due to retest variability of conventional Hct. Scanner- and sequence-specific formulas should be used.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Hematocrit - administration & dosage
Male - administration & dosage
Female - administration & dosage
Middle Aged - administration & dosage
Retrospective Studies - administration & dosage
Reproducibility of Results - administration & dosage
Magnetic Resonance Imaging - methods
Adult - administration & dosage
Aged - administration & dosage
Image Interpretation, Computer-Assisted - methods
Sensitivity and Specificity - administration & dosage
Algorithms - administration & dosage

Find related publications in this database (Keywords)
Synthetic ECV
Cardiac magnetic resonance imaging
Hematocrit
Extracellular volume
T1 mapping
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