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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Sattler, S; Ljubojevic-Holzer, S.
CD8+ T cells as the missing link between doxorubicin cancer therapy and heart failure risk.
Nat Cardiovasc Res. 2024; 3(8):890-892
Doi: 10.1038/s44161-024-00513-0
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Sattler Susanne
- Co-authors Med Uni Graz
- Holzer Senka
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- Abstract:
- Doxorubicin treatment is a mainstay of cancer therapy but causes potent cardiotoxicity that exposes cancer survivors to the risk of heart failure. A study now identifies CD8(+) T cells of the adaptive immune system as major culprits in the development of doxorubicin-induced cardiomyopathy and heart failure.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Humans - administration & dosage
- Antibiotics, Antineoplastic - adverse effects, therapeutic use
- Cardiotoxicity - etiology
- CD8-Positive T-Lymphocytes - immunology, drug effects
- Doxorubicin - adverse effects, therapeutic use
- Heart Failure - immunology
- Risk Factors - administration & dosage