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Parwani, AS; Kääb, S; Friede, T; Tilz, RR; Bauersachs, J; Frey, N; Hindricks, G; Lewalter, T; Rienstra, M; Rillig, A; Scherr, D; Steven, D; Kirchhof, P; Pieske, B.
Catheter-based ablation to improve outcomes in patients with atrial fibrillation and heart failure with preserved ejection fraction: Rationale and design of the CABA-HFPEF-DZHK27 trial.
Eur J Heart Fail. 2024; 26(10):2203-2212 Doi: 10.1002/ejhf.3373
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Co-Autor*innen der Med Uni Graz
Scherr Daniel
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Abstract:
AIMS: Atrial fibrillation (AF) is common in heart failure (HF) and negatively impacts outcomes. The role of ablation-based rhythm control in patients with AF and HF with preserved (HFpEF) or mildly reduced ejection fraction (HFmrEF) is not known. The CABA-HFPEF-DZHK27 (CAtheter-Based Ablation of atrial fibrillation compared to conventional treatment in patients with Heart Failure with Preserved Ejection Fraction) trial will determine whether early catheter ablation for AF can prevent adverse cardiovascular outcomes in patients with HFpEF or HFmrEF. METHODS: CABA-HFPEF-DZHK27 (NCT05508256) is an investigator-initiated, prospective, randomized, open, interventional multicentre strategy trial with blinded outcome assessment. Approximately 1548 patients with paroxysmal or persistent AF diagnosed within 24 months prior to enrolment and HFpEF or HFmrEF will be randomized to early catheter ablation within 4 weeks after randomization or to usual care. All patients receive anticoagulation, rate control, and HF management according to current guideline recommendations. Usual care can include rhythm control in symptomatic patients. Patients will be followed until the end of the trial for the primary outcome, a composite of cardiovascular death, stroke, and total unplanned hospitalizations for HF or acute coronary syndrome. The safety outcome comprises complications of catheter ablation and death. The trial is powered for a rate ratio of 0.75 (two-sided alpha = 0.05, 1-beta = 0.8). CONCLUSION: CABA-HFPEF-DZHK27 will define the role of systematic and early catheter ablation in patients with AF and HFpEF or HFmrEF.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Atrial Fibrillation - surgery, physiopathology, therapy
Heart Failure - physiopathology, therapy, complications
Catheter Ablation - methods
Stroke Volume - physiology
Prospective Studies - administration & dosage
Female - administration & dosage
Male - administration & dosage
Treatment Outcome - administration & dosage
Aged - administration & dosage
Middle Aged - administration & dosage

Find related publications in this database (Keywords)
Atrial fibrillation
Heart failure with preserved ejection fraction
Heart failure with mildly reduced ejection fraction
Catheter ablation
Usual medical care
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