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Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kölblinger, F; Schönthaler, EM; Baranyi, A; Stross, T; Fellendorf, FT; von, Lewinski, D; Queissner, R; Reininghaus, EZ; Dalkner, N.
Better understanding of c-reactive protein and leukocytes in psychiatric inpatients with affective disorders: A biopsychosocial approach.
World J Clin Cases. 2024; 12(19): 3824-3836.
Doi: 10.12998/wjcc.v12.i19.3824
[OPEN ACCESS]
PubMed
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- Führende Autor*innen der Med Uni Graz
- Schönthaler Elena
- Co-Autor*innen der Med Uni Graz
- Baranyi Andreas
- Dalkner Nina
- Fellendorf Frederike
- Queissner Robert
- Reininghaus Eva
- Stross Tatjana Maria
- von Lewinski Dirk
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- Abstract:
- BACKGROUND: Affective disorders (AD) have been linked to inflammatory processes, although the underlying mechanisms of this relationship are still not fully elucidated. It is hypothesized that demographic, somatic, lifestyle, and personality variables predict inflammatory parameters in AD. AIM: To identify biopsychosocial factors contributing to inflammation in AD measured with two parameters, C-reactive protein (CRP) and leukocytes. METHODS: This observational study investigated 186 hospital inpatients diagnosed with AD using demographic parameters, serum inflammatory markers, somatic variables, psychological questionnaires, and lifestyle parameters. Hierarchical regression analyses were used to predict inflammatory markers from demographic, somatic, lifestyle, and personality variables. RESULTS: Analyses showed that 33.8% of the variance of CRP was explained by body mass index and other somatic medication (e.g. anti-diabetics), age and education, and age of affective disorder diagnosis. For leukocytes, 20.1% of the variance was explained by smoking, diet, metabolic syndrome (MetS), and anti-inflammatory medication (e.g. non-steroidal anti-inflammatory drugs). Other psychiatric or behavioural variables did not reach significance. CONCLUSION: Metabolic components seem important, with mounting evidence for a metabolic affective disorder subtype. Lifestyle modifications and psychoeducation should be employed to prevent or treat MetS in AD.