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SHR Neuro Cancer Cardio Lipid Metab Microb
du, Fay, de, Lavallaz, J; Badertscher, P; Ghannam, M; Oral, H; Jongnarangsin, K; Boveda, S; Madeira, M; Gupta, D; Ding, WY; Providencia, R; MacLean, E; Tokuda, M; Tokutake, K; Reichlin, T; Zhang, F; Scherr, D; Popa, MA; Huang, H; Pavlović, N; Peigh, G; Li, X; Davtyan, K; Kosmidou, I; Anselmino, M; Jain, S; Squara, F; Nof, E; Matta, M; Kojodjojo, P; Khoueiry, Z; Knecht, S; Krisai, P; Sticherling, C; Kühne, M.
Severe Periprocedural Complications After Ablation for Atrial Fibrillation: An International Collaborative Individual Patient Data Registry.
JACC Clin Electrophysiol. 2024; 10(7 Pt 1):1353-1364
Doi: 10.1016/j.jacep.2024.03.024
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Scherr Daniel
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- Abstract:
- BACKGROUND: Catheter ablation for atrial fibrillation (AF) including pulmonary vein isolation and possibly further substrate ablation is the most common electrophysiological procedure. Severe complications are uncommon, but their detailed assessment in a large worldwide cohort is lacking. OBJECTIVES: The aim of this study was to determine the incidence of periprocedural severe complications and to provide a detailed characterization of the diagnostic evaluation and management of these complications in patients undergoing AF ablation. METHODS: Individual patient data were collected from 23 centers worldwide. Limited data were collected for all patients who underwent catheter ablation, and an expanded series of data points were collected for patients who experienced severe complications during periprocedural follow-up. Incidence, predictors, patient characteristics, management details, and overall outcomes of patients who experienced ablation-related complications were investigated. RESULTS: Data were collected from 23 participating centers at which 33,879 procedures were performed (median age 63 years, 30% women, 71% radiofrequency ablations). The incidence of severe complications (n = 271) was low (tamponade 6.8‰, stroke 0.97‰, cardiac arrest 0.41‰, esophageal fistula 0.21‰, and death 0.21‰). Age, female sex, a dilated left atrium, procedure duration, and the use of radiofrequency energy were independently associated with the composite endpoint of all severe complications. Among patients experiencing tamponade, 13% required cardiac surgery. Ninety-three percent of patients with complications were discharged directly home after a median length of stay of 5 days (Q1-Q3: 3-7 days). CONCLUSIONS: This large worldwide collaborative study highlighted that tamponade, stroke, cardiac arrest, esophageal fistula, and death are rare after AF ablation. Older age, female sex, procedure duration, a dilated left atrium, and the use of radiofrequency energy were associated with severe complications in this multinational cohort. One in 8 patients with tamponade required cardiac surgery.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Atrial Fibrillation - surgery
- Male - administration & dosage
- Female - administration & dosage
- Catheter Ablation - adverse effects
- Middle Aged - administration & dosage
- Aged - administration & dosage
- Postoperative Complications - epidemiology
- Registries - administration & dosage
- Incidence - administration & dosage
- Cardiac Tamponade - epidemiology, etiology
- Stroke - epidemiology
- Esophageal Fistula - epidemiology, etiology
- Find related publications in this database (Keywords)
- atrial fibrillation
- cardiac arrest
- catheter ablation
- complications
- esophageal fistula
- incidence
- predictors
- pulmonary vein isolation
- stroke
- tamponade