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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Xu, R; Vujić, N; Bianco, V; Reinisch, I; Kratky, D; Krstic, J; Prokesch, A.
Lipid-associated macrophages between aggravation and alleviation of metabolic diseases.
Trends Endocrinol Metab. 2024; Doi: 10.1016/j.tem.2024.04.009
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Führende Autor*innen der Med Uni Graz
Prokesch Andreas
Xu Ruonan
Co-Autor*innen der Med Uni Graz
Bianco Valentina
Kratky Dagmar
Krstic Jelena
Reinisch Isabel Nadine
Vujic Nemanja
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Abstract:
Lipid-associated macrophages (LAMs) are phagocytic cells with lipid-handling capacity identified in various metabolic derangements. During disease development, they locate to atherosclerotic plaques, adipose tissue (AT) of individuals with obesity, liver lesions in steatosis and steatohepatitis, and the intestinal lamina propria. LAMs can also emerge in the metabolically demanding microenvironment of certain tumors. In this review, we discuss major questions regarding LAM recruitment, differentiation, and self-renewal, and, ultimately, their acute and chronic functional impact on the development of metabolic diseases. Further studies need to clarify whether and under which circumstances LAMs drive disease progression or resolution and how their phenotype can be modulated to ameliorate metabolic disorders.

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