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SHR Neuro Cancer Cardio Lipid Metab Microb
Schwegel, N; Zach, D; Peikert, A; Santner, V; Höller, V; Gollmer, J; Späth, J; Riepl, H; Rainer, PP; Wallner, M; Pilz, S; Zirlik, A; von, Lewinski, D; Ablasser, K; Verheyen, N; Kolesnik, E.
The Prognostic Value of Right Ventricular Function in Patients with Chronic Heart Failure-A Prospective Study.
J Clin Med. 2024; 13(7): 1930
Doi: 10.3390/jcm13071930
[OPEN ACCESS]
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Schwegel Nora
- Verheyen Nicolas Dominik
- Co-authors Med Uni Graz
- Ablasser Klemens
- Höller Viktoria
- Kolesnik Ewald
- Peikert Alexander
- Pilz Stefan
- Rainer Peter
- Riepl Hermann Stefan
- Santner Viktoria
- von Lewinski Dirk
- Wallner Markus
- Zach David
- Zirlik Andreas
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- Abstract:
- Background: In patients with stable chronic heart failure with a reduced ejection fraction (HFrEF), left ventricular ejection fraction (LVEF) provides limited prognostic value, especially in patients with moderately to severely reduced LVEF. Echocardiographic parameters of right ventricular function may be associated with adverse clinical events in these patients. Therefore, we analyzed 164 patients with HFrEF in a prospective single-center cohort study to evaluate whether the parameters of right ventricular function are associated with worsening heart failure (WHF) hospitalizations, cardiovascular and all-cause deaths and combined endpoints. Methods: Echocardiographic cine loops were analyzed using vendor-independent post-processing software. Multivariate Cox regression analyses were performed, which were then adjusted for clinical characteristics and left ventricular functional parameters. Results: In these models, higher tricuspid annular plane systolic excursion (TAPSE) was significantly associated with lower rates of WHF hospitalizations (HR 0.880, 95%CI 0.800-0.968, p = 0.008), a composite endpoint of WHF hospitalizations and cardiovascular death (HR 0.878, 95%CI 0.800-0.964, p = 0.006), and a composite endpoint of WHF hospitalization and all-cause death (HR 0.918, 95%CI 0.853-0.988, p = 0.023). These associations were more pronounced in patients with LVEF ≤ 35%. Conclusions: In conclusion, in patients with HFrEF, TAPSE is an independent prognosticator for adverse clinical outcomes, warranting further studies to elucidate whether incorporating TAPSE into established risk scores improves their diagnostic accuracy.
- Find related publications in this database (Keywords)
- chronic heart failure
- HFrEF
- right ventricular function