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Zelzer, S; Meinitzer, A; Enko, D; Keppel, MH; Herrmann, M; Theiler-Schwetz, V; Trummer, C; Schmitt, L; Tomaschitz, A; Sadoghi, P; Dierkes, J; Pludowski, P; Zittermann, A; März, W; Pilz, S.
Classification of Vitamin D Status Based on Vitamin D Metabolism: A Randomized Controlled Trial in Hypertensive Patients.
Nutrients. 2024; 16(6): Doi: 10.3390/nu16060839 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Pilz Stefan
Zelzer Sieglinde
Co-Autor*innen der Med Uni Graz
Enko Dietmar
Herrmann Markus
Keppel Martin Helmut
März Winfried
Meinitzer Andreas
Sadoghi Patrick
Schmitt Lisa Maria
Theiler-Schwetz Verena
Tomaschitz Andreas
Trummer Christian
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Abstract:
Circulating 25-hydroxyvitamin D (25(OH)D) is the generally accepted indicator of vitamin D status. Since hydroxylation of 25(OH)D to 24-25-dihydroxyvitamin D (24,25(OH)2D) is the first step of its catabolism, it has been suggested that a low 24,25(OH)D level and a low vitamin D metabolite ratio (VMR), i.e., 24,25(OH)2D divided by 25(OH)D, may indicate high vitamin D requirements and provide additional diagnostic information beyond serum 25(OH)D. We, therefore, evaluated whether the classification of "functional vitamin D deficiency", i.e., 25(OH)D below 50 nmol/L, 24,25(OH)2D below 3 nmol/L and a VMR of less than 4%, identifies individuals who benefit from vitamin D supplementation. In participants of the Styrian Vitamin D Hypertension trial, a randomized controlled trial (RCT) in 200 hypertensive patients with serum 25(OH)D below 75 nmol/L, who received either 2.800 international units of vitamin D per day or placebo over 8 weeks, 51 participants had functional vitamin D deficiency. In these individuals, there was no treatment effect of vitamin D supplementation on various parameters of bone metabolism and cardiovascular risk except for a significant effect on parathyroid hormone (PTH) and expected changes in vitamin D metabolites. In conclusion, a low vitamin D metabolite profile did not identify individuals who significantly benefit from vitamin D supplementation with regard to bone markers and cardiovascular risk factors. The clinical significance of functional vitamin D deficiency requires further evaluation in large vitamin D RCTs.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Vitamin D - administration & dosage
Calcifediol - administration & dosage
Vitamin D Deficiency - administration & dosage
Vitamins - therapeutic use
Parathyroid Hormone - administration & dosage
Hypertension - drug therapy
Dietary Supplements - administration & dosage

Find related publications in this database (Keywords)
vitamin D
vitamin D metabolite ratio
RCT
supplementation
deficiency
24,25-dihydroxyvitamin D
classification
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