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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Wilmanski, T; Diener, C; Rappaport, N; Patwardhan, S; Wiedrick, J; Lapidus, J; Earls, JC; Zimmer, A; Glusman, G; Robinson, M; Yurkovich, JT; Kado, DM; Cauley, JA; Zmuda, J; Lane, NE; Magis, AT; Lovejoy, JC; Hood, L; Gibbons, SM; Orwoll, ES; Price, ND.
Gut microbiome pattern reflects healthy ageing and predicts survival in humans.
Nat Metab. 2021; 3(2): 274-286. Doi: 10.1038/s42255-021-00348-0 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz
Diener Christian
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Abstract:
The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with age. We leverage three independent cohorts comprising over 9,000 individuals and find that compositional uniqueness is strongly associated with microbially produced amino acid derivatives circulating in the bloodstream. In older age (over ~80 years), healthy individuals show continued microbial drift towards a unique compositional state, whereas this drift is absent in less healthy individuals. The identified microbiome pattern of healthy ageing is characterized by a depletion of core genera found across most humans, primarily Bacteroides. Retaining a high Bacteroides dominance into older age, or having a low gut microbiome uniqueness measure, predicts decreased survival in a 4-year follow-up. Our analysis identifies increasing compositional uniqueness of the gut microbiome as a component of healthy ageing, which is characterized by distinct microbial metabolic outputs in the blood.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent - administration & dosage
Adult - administration & dosage
Aged - administration & dosage
Aged, 80 and over - administration & dosage
Amino Acids - blood
Bacteroides - metabolism
Cohort Studies - administration & dosage
Female - administration & dosage
Gastrointestinal Microbiome - physiology
Healthy Aging - physiology
Humans - administration & dosage
Life Style - administration & dosage
Male - administration & dosage
Metabolomics - administration & dosage
Middle Aged - administration & dosage
Predictive Value of Tests - administration & dosage
Survival Analysis - administration & dosage
Young Adult - administration & dosage

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