Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Scholz, M; Horn, K; Pott, J; Wuttke, M; Kühnapfel, A; Nasr, MK; Kirsten, H; Li, Y; Hoppmann, A; Gorski, M; Ghasemi, S; Li, M; Tin, A; Chai, JF; Cocca, M; Wang, J; Nutile, T; Akiyama, M; Åsvold, BO; Bansal, N; Biggs, ML; Boutin, T; Brenner, H; Brumpton, B; Burkhardt, R; Cai, J; Campbell, A; Campbell, H; Chalmers, J; Chasman, DI; Chee, ML; Chee, ML; Chen, X; Cheng, CY; Cifkova, R; Daviglus, M; Delgado, G; Dittrich, K; Edwards, TL; Endlich, K; Michael, Gaziano, J; Giri, A; Giulianini, F; Gordon, SD; Gudbjartsson, DF; Hallan, S; Hamet, P; Hartman, CA; Hayward, C; Heid, IM; Hellwege, JN; Holleczek, B; Holm, H; Hutri-Kähönen, N; Hveem, K; Isermann, B; Jonas, JB; Joshi, PK; Kamatani, Y; Kanai, M; Kastarinen, M; Khor, CC; Kiess, W; Kleber, ME; Körner, A; Kovacs, P; Krajcoviechova, A; Kramer, H; Krämer, BK; Kuokkanen, M; Kähönen, M; Lange, LA; Lash, JP; Lehtimäki, T; Li, H; Lin, BM; Liu, J; Loeffler, M; Lyytikäinen, LP; Magnusson, PKE; Martin, NG; Matsuda, K; Milaneschi, Y; Mishra, PP; Mononen, N; Montgomery, GW; Mook-Kanamori, DO; Mychaleckyj, JC; März, W; Nauck, M; Nikus, K; Nolte, IM; Noordam, R; Okada, Y; Olafsson, I; Oldehinkel, AJ; Penninx, BWJH; Perola, M; Pirastu, N; Polasek, O; Porteous, DJ; Poulain, T; Psaty, BM; Rabelink, TJ; Raffield, LM; Raitakari, OT; Rasheed, H; Reilly, DF; Rice, KM; Richmond, A; Ridker, PM; Rotter, JI; Rudan, I; Sabanayagam, C; Salomaa, V; Schneiderman, N; Schöttker, B; Sims, M; Snieder, H; Stark, KJ; Stefansson, K; Stocker, H; Stumvoll, M; Sulem, P; Sveinbjornsson, G; Svensson, PO; Tai, ES; Taylor, KD; Tayo, BO; Teren, A; Tham, YC; Thiery, J; Thio, CHL; Thomas, LF; Tremblay, J; Tönjes, A; van, der, Most, PJ; Vitart, V; Völker, U; Wang, YX; Wang, C; Wei, WB; Whitfield, JB; Wild, SH; Wilson, JF; Winkler, TW; Wong, TY; Woodward, M; Sim, X; Chu, AY; Feitosa, MF; Thorsteinsdottir, U; Hung, AM; Teumer, A; Franceschini, N; Parsa, A; Köttgen, A; Schlosser, P; Pattaro, C.
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements.
Nat Commun. 2024; 15(1): 586 Doi: 10.1038/s41467-024-44709-1 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz
März Winfried
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-related traits (n = 908,697), identifying 23 loci genome-wide significantly associated with two of the traits: 7 for uric acid and 16 for estimated glomerular filtration rate (eGFR), including four novel eGFR loci containing the functionally plausible prioritized genes ACSL4, CLDN2, TSPAN6 and the female-specific DRP2. Further, we identified five novel sex-interactions, comprising male-specific effects at FAM9B and AR/EDA2R, and three sex-differential findings with larger genetic effect sizes in males at DCAF12L1 and MST4 and larger effect sizes in females at HPRT1. All prioritized genes in loci showing significant sex-interactions were located next to androgen response elements (ARE). Five ARE genes showed sex-differential expressions. This study contributes new insights into sex-dimorphisms of kidney traits along with new prioritized gene targets for further molecular research.
Find related publications in this database (using NLM MeSH Indexing)
Humans - administration & dosage
Male - administration & dosage
Female - administration & dosage
Androgens - genetics
Genome-Wide Association Study - administration & dosage
Kidney - administration & dosage
Chromosomes, Human, X - genetics
Response Elements - administration & dosage
Polymorphism, Single Nucleotide - administration & dosage
Genetic Predisposition to Disease - administration & dosage
Tetraspanins - genetics

© Med Uni Graz • Impressum