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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Grabner, GF; Xie, H; Schweiger, M; Zechner, R.
Lipolysis: cellular mechanisms for lipid mobilization from fat stores.
Nat Metab. 2021; 3(11): 1445-1465.
Doi: 10.1038/s42255-021-00493-6
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- Leading authors Med Uni Graz
- Grabner Gernot
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- Abstract:
- The perception that intracellular lipolysis is a straightforward process that releases fatty acids from fat stores in adipose tissue to generate energy has experienced major revisions over the last two decades. The discovery of new lipolytic enzymes and coregulators, the demonstration that lipophagy and lysosomal lipolysis contribute to the degradation of cellular lipid stores and the characterization of numerous factors and signalling pathways that regulate lipid hydrolysis on transcriptional and post-transcriptional levels have revolutionized our understanding of lipolysis. In this review, we focus on the mechanisms that facilitate intracellular fatty-acid mobilization, drawing on canonical and noncanonical enzymatic pathways. We summarize how intracellular lipolysis affects lipid-mediated signalling, metabolic regulation and energy homeostasis in multiple organs. Finally, we examine how these processes affect pathogenesis and how lipolysis may be targeted to potentially prevent or treat various diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - drug effects, physiology
- Animals - administration & dosage
- Biomarkers - administration & dosage
- Disease Management - administration & dosage
- Disease Susceptibility - administration & dosage
- Energy Metabolism - drug effects
- Fatty Acids - metabolism
- Gene Expression Regulation, Enzymologic - administration & dosage
- Humans - administration & dosage
- Lipid Mobilization - drug effects
- Lipolysis - drug effects, physiology
- Metabolic Networks and Pathways - drug effects
- Molecular Targeted Therapy - administration & dosage
- Protein Processing, Post-Translational - administration & dosage
- Triglycerides - metabolism