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Niestrawska, JA; Spronck, B; Cavinato, C; Humphrey, JD.
Tempol improves aortic mechanics in a mouse model of hypertension.
J Biomech. 2024; 162:111911 Doi: 10.1016/j.jbiomech.2023.111911 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Niestrawska Justyna Anna
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Abstract:
Hypertension-induced arterial remodeling is thought to be a response to increases in both mechanical stress and oxidative stress. The superoxide dismutase mimetic Tempol has been shown to reduce adverse aortic remodeling in multiple murine models of hypertension but in the absence of a detailed assessment of the biaxial biomechanics. We show that concurrent treatment with Tempol in a common mouse model of systemic hypertension results in modest reductions in both wall thickening and circumferential material stiffness that yet work together to achieve a significant reduction in calculated aortic pulse wave velocity. Reducing elevated values of pulse wave velocity engenders multiple benefits to cardiovascular function.
Find related publications in this database (using NLM MeSH Indexing)
Mice - administration & dosage
Animals - administration & dosage
Pulse Wave Analysis - administration & dosage
Hypertension - drug therapy
Cyclic N-Oxides - pharmacology
Spin Labels - administration & dosage
Disease Models, Animal - administration & dosage
Blood Pressure - physiology
Vascular Stiffness - physiology

Find related publications in this database (Keywords)
Artery
Blood pressure
Mechanical stress
Oxidative stress
Inflammation
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