Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Zach, DK; Schwegel, N; Santner, V; Winkelbauer, L; Hoeller, V; Kolesnik, E; Gollmer, J; Seggewiss, H; Batzner, A; Perl, S; Wallner, M; Reiter, U; Rainer, PP; Zirlik, A; Ablasser, K; Verheyen, N.
Low-grade systemic inflammation and left ventricular dysfunction in hypertensive compared to non-hypertensive hypertrophic cardiomyopathy.
Int J Cardiol. 2024; 399:131661 Doi: 10.1016/j.ijcard.2023.131661
Web of Science PubMed FullText FullText_MUG

 

Führende Autor*innen der Med Uni Graz
Zach David
Co-Autor*innen der Med Uni Graz
Ablasser Klemens
Gollmer Johannes
Höller Viktoria
Kolesnik Ewald
Perl Sabine
Rainer Peter
Reiter Ursula
Santner Viktoria
Schwegel Nora
Verheyen Nicolas Dominik
Wallner Markus
Zirlik Andreas
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
BACKGROUND: Arterial hypertension (HTN) is associated with excess mortality in hypertrophic cardiomyopathy (HCM), but underlying mechanisms are largely elusive. The objective of this study was to investigate the association between HTN and markers of left ventricular (LV) dysfunction and low-grade systemic inflammation in a HCM cohort. METHODS: This was a single-center cross-sectional case-control study comparing echocardiographic and plasma-derived indices of LV dysfunction and low-grade systemic inflammation between 30 adult patients with HCM and HTN (HTN+) and 30 sex- and age-matched HCM patients without HTN (HTN-). Echocardiographic measures were assessed using post-processing analyses by blinded investigators. RESULTS: Mean age of the study population was 55.1 ± 10.4 years, 30% were women. Echocardiographic measures of systolic and diastolic dysfunction, including speckle-tracking derived parameters, did not differ between HTN+ and HTN-. Moreover, levels of N-terminal pro B-type natriuretic peptide were balanced between cases and controls. Compared with HTN-, HTN+ patients exhibited a higher white blood cell count [8.1 ± 1.8 109/l vs. 6.4 ± 1.6 109/l; p < 0.001] as well as higher plasma levels of interleukin-6 [2.8 pg/ml (2.0, 5.4) vs. 2.1 pg/ml (1.5, 3.4); p = 0.008] and high-sensitivity C-reactive protein [2.6 mg/l (1.4, 6.5) vs. 1.1 mg/l (0.9, 2.4); p = 0.004]. CONCLUSION: This study demonstrates that HTN is associated with indices of low-grade systemic inflammation among HCM patients. Moreover, this analysis indicates that the adverse impact of HTN in HCM patients is a consequence of systemic effects rather than alterations of cardiac function, as measures of LV systolic and diastolic dysfunction did not differ between HTN+ and HTN-.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Humans - administration & dosage
Female - administration & dosage
Middle Aged - administration & dosage
Aged - administration & dosage
Male - administration & dosage
Case-Control Studies - administration & dosage
Cross-Sectional Studies - administration & dosage
Cardiomyopathy, Hypertrophic - complications, diagnostic imaging
Ventricular Dysfunction, Left - administration & dosage
Hypertension - administration & dosage
Inflammation - diagnostic imaging, complications
Hypertrophy, Left Ventricular - administration & dosage

Find related publications in this database (Keywords)
Hypertrophic cardiomyopathy
Hypertension
Inflammation
Left ventricular dysfunction
© Med Uni Graz • Impressum